Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALB | P02768 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.34 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL783714 | 0.80 | LMNA (0.59) | LMNAPKMNPSR1ALDH1A1MAPT | |
| SCHEMBL7413765 | 0.78 | FFAR4 (0.42) | LMNAPKMNPSR1ALDH1A1MAPT | |
| SCHEMBL2548565 | 0.78 | LMNA (0.44) | LMNAPKMNPSR1ALDH1A1MAPT | |
| SCHEMBL15625037 | 0.71 | PKM (0.39) | LMNAPKMNPSR1ALDH1A1MAPT | |
| SCHEMBL672668 | 0.71 | LMNA (0.44) | LMNAPKMNPSR1ALDH1A1MAPT | |
| SCHEMBL21845449 | 0.70 | TRPA1 (0.42) | ALDH1A1ALOX15TSHRALBCXCR5 | |
| SCHEMBL11094419 | 0.69 | PARP1 (0.49) | ALDH1A1MAPTKDM4EALOX15TSHR | |
| SCHEMBL11797726 | 0.69 | ALDH1A1 (0.44) | ALDH1A1KDM4EALOX15TSHRALB | |
| SCHEMBL29710998 | 0.69 | ALOX5 (0.41) | ALDH1A1KDM4EALOX15TSHRALB | |
| SCHEMBL14297655 | 0.69 | GABRA1 (0.36) | LMNATSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038200-A1 | OXAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-08 | — | — | WO | claimed |
| WO-2010038200-A1 | OXAZOLIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-08 | — | — | WO | disclosed |