SCHEMBL33517

SCHEMBL33517

C=C(C)C(=O)NCCCN=C=O

nearest known ligand 0.40

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KEAP1 Q14145 3/20 0.40
NFE2L2 Q16236 3/20 0.40
KDM4E B2RXH2 2/20 0.33
MAPK1 P28482 1/20 0.33
HIF1A Q16665 1/20 0.33
TGFBR1 P36897 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL465655 0.95 KEAP1 (0.42) KEAP1NFE2L2KDM4EMAPK1HIF1A
SCHEMBL19988824 0.93 KEAP1 (0.41) KEAP1NFE2L2KDM4EMAPK1HIF1A
SCHEMBL465815 0.89 TGFBR1 (0.32) TGFBR1
SCHEMBL81704 0.84 KEAP1 (0.58) KEAP1NFE2L2
SCHEMBL16803277 0.79 KDM4E (0.37) KEAP1NFE2L2KDM4EMAPK1HIF1A
SCHEMBL19998248 0.79 KDM4E (0.37) KEAP1NFE2L2KDM4EMAPK1HIF1A
SCHEMBL907569 0.78 KDM4E (0.52) KDM4EMAPK1HIF1ATGFBR1
SCHEMBL632876 0.78 KDM4E (0.46) KDM4EMAPK1HIF1ATGFBR1
SCHEMBL14865406 0.78 KDM4E (0.35) KEAP1NFE2L2KDM4EMAPK1HIF1A
SCHEMBL465638 0.77 TGFBR1 (0.33) TGFBR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12447228-B2 Polymer particles TERUMO CORPORATION (JP) 2025-10-21 US disclosed
EP-3518983-B1 POLYMER PARTICLES TERUMO CORP (JP) 2024-04-24 EP disclosed
US-20230190991-A1 POLYMER PARTICLES TERUMO CORPORATION (JP) 2023-06-22 US disclosed
US-11617814-B2 Methods of treatment comprising administering polymer particles configured for intravascular delivery of pharmaceutical agents TERUMO CORPORATION (JP) 2023-04-04 US disclosed
CN-109789222-B Polymer particles 泰尔茂株式会社 2022-02-25 CN disclosed
US-20200324016-A1 POLYMER PARTICLES MICROVENTION, INC. 2020-10-15 US disclosed
US-10729805-B2 Drug delivery polymer particles with hydrolytically degradable linkages TERUMO CORPORATION (JP) 2020-08-04 US disclosed
US-20190255213-A1 POLYMER PARTICLES MICROVENTION, INC. 2019-08-22 US disclosed
EP-3518983-A1 POLYMER PARTICLES Terumo Corporation (JP) 2019-08-07 EP disclosed
US-10328175-B2 Polymer particles TERUMO CORPORATION (JP) 2019-06-25 US disclosed
WO-2006068852-A1 SOLVENT RESISTANT IMAGEABLE ELEMENT EASTMAN KODAK COMPANY (US) 2006-06-29 WO disclosed
US-6969579-B1 top layer containing a co-polymer of an unsaturated compound containing an imide group and a comonomer selected from an acryl imides, acrylonitriles, acryalmides and acrylic acids; chemical resistance printing plate EASTMAN KODAK COMPANY (US) 2005-11-29 US disclosed
EP-0146326-B1 SULFOPOLYESTER-CONTAINING PHOTOPOLYMER SYSTEMS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1991-03-13 EP disclosed
US-4956265-A POLYUNSATURATED WITH ESTER AND CARBOXY GROUPS; PROTECTIVE COATINGS, GRAPHIC ARTS, PHOTORESTS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1990-09-11 US disclosed
US-4914165-A PHOTOCROSSLINKABLE POLYEPOXIDE POLYESTERS USING POLY (ETHYLENICALLY-UNSATURATED)ALKANOLS AND DICARBOXYLIC ACIDS; PROTECTIVE COATINGS; GRAPHIC ARTS; WEAR RESISTANCE; ADHESION MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1990-04-03 US disclosed
EP-0329298-A2 Radiation crosslinkable compositions MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1989-08-23 EP disclosed
US-4855384-A POLYURETHANES FROM POLYESTERS OR POLY OF SULFOAROMATIC DICARBOCYLIC ACIDS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1989-08-08 US disclosed
US-4746717-A COATINGS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1988-05-24 US disclosed
US-4558149-A FILMS;COATINGS;PHOTORESISTS;LOW MOLECULAR WEIGHT MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1985-12-10 US disclosed
EP-0146326-A2 Sulfopolyester-containing photopolymer systems MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1985-06-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11617814-B2 Methods of treatment comprising administering polymer particles configured for intravascular delivery of pharmaceutical agents PLG, LPXN, PLAU KEAP1 3292/4885NFE2L2 4565/4885KDM4E 4482/4885
US-12447228-B2 Polymer particles PCBP1, LCP1, PSAP KEAP1 4606/4885NFE2L2 4692/4885KDM4E 4411/4885
US-10729805-B2 Drug delivery polymer particles with hydrolytically degradable linkages MMP1, GUSB, PRCP KEAP1 3779/4885NFE2L2 4567/4885KDM4E 3543/4885
US-20190255213-A1 POLYMER PARTICLES PCBP1, LCP1, PSAP KEAP1 4605/4885NFE2L2 4692/4885KDM4E 4411/4885
US-10328175-B2 Polymer particles PCBP1, LCP1, PSAP KEAP1 4606/4885NFE2L2 4692/4885KDM4E 4411/4885
US-20200324016-A1 POLYMER PARTICLES PCBP1, LCP1, PSAP KEAP1 4606/4885NFE2L2 4692/4885KDM4E 4411/4885
US-20230190991-A1 POLYMER PARTICLES PCBP1, LCP1, PSAP KEAP1 4606/4885NFE2L2 4692/4885KDM4E 4411/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.