Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 13/20 | 0.45 |
| ▸ | ICMT | O60725 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3353571 | 0.90 | ACHE (0.51) | NR1H2LMNAGLAALDH1A1TSHR | |
| SCHEMBL3350921 | 0.89 | ACHE (0.50) | NR1H2LMNAGLAALDH1A1TSHR | |
| SCHEMBL3358868 | 0.89 | NR1H2 (0.53) | NR1H2LMNAGLAALDH1A1TSHR | |
| SCHEMBL3356705 | 0.87 | HTR1D (0.47) | NR1H2LMNAGLATSHRHTR6 | |
| SCHEMBL3357664 | 0.86 | HRH3 (0.47) | NR1H2LMNAGLAALDH1A1TSHR | |
| SCHEMBL19140058 | 0.81 | HTR6 (0.66) | HTR6CYP3A4CYP2D6ADRB2 | |
| SCHEMBL13537255 | 0.80 | LMNA (0.46) | LMNAGLAALDH1A1TSHRHTR6 | |
| SCHEMBL3353450 | 0.78 | HTR6 (0.62) | LMNAGLAALDH1A1HTR6 | |
| SCHEMBL3355548 | 0.77 | HTR1D (0.48) | HTR6ADRB2 | |
| SCHEMBL3353653 | 0.77 | ACHE (0.50) | NR1H2LMNAGLAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |