Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 15/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ICMT | O60725 | 1/20 | 0.40 |
| ▸ | BCL6 | P41182 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3351825 | 0.92 | ACHE (0.44) | NR1H2ICMT | |
| SCHEMBL3352252 | 0.91 | CACNB4 (0.43) | ICMT | |
| SCHEMBL3353615 | 0.89 | HRH3 (0.41) | ICMT | |
| SCHEMBL3357970 | 0.84 | NR1H2 (0.47) | NR1H2HTR6LMNAICMT | |
| SCHEMBL13537213 | 0.83 | BCL6 (0.44) | HTR6ICMTBCL6CYP3A4CYP2D6 | |
| SCHEMBL3351079 | 0.81 | HTR6 (0.48) | HTR6 | |
| SCHEMBL3358868 | 0.81 | NR1H2 (0.53) | NR1H2HTR6LMNACYP3A4CYP2D6 | |
| SCHEMBL3349651 | 0.78 | HTR6 (0.41) | HTR6ICMT | |
| SCHEMBL3357817 | 0.76 | ALDH1A1 (0.53) | LMNA | |
| SCHEMBL13537295 | 0.74 | HDAC3 (0.42) | LMNAICMTBCL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |