Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | COMT | P21964 | 4/20 | 0.41 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL147797 | 0.86 | KDM4E (0.55) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL15964171 | 0.83 | ALDH1A1 (0.56) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL13990963 | 0.83 | ALDH1A1 (0.51) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL4628901 | 0.79 | PTGS2 (0.53) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL23619123 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL3729672 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL312571 | 0.79 | CYP1A2 (0.59) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL14194615 | 0.79 | KDM4E (0.55) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL146809 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KDM4ECYP1A2HPGDBLM | |
| SCHEMBL16496891 | 0.78 | TYR (0.34) | TYR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680123-B1 | Substituted N-aryl pyridinones | AUSPEX PHARMACEUTICALS, INC (US) | 2014-03-25 | — | — | US | disclosed |
| US-8383823-B2 | Substituted N-aryl pyridinones | AUSPEX PHARMACEUTICALS (US) | 2013-02-26 | — | — | US | disclosed |
| US-20110313004-A1 | DEUTERATED PYRIDINONES | CONCERT PHARMACEUTICALS, INC. (US) | 2011-12-22 | — | — | US | disclosed |
| WO-2010065755-A1 | DEUTERATED PYRIDINONES | CONCERT PHARMACEUTICALS, INC. (US) | 2010-06-10 | — | — | WO | disclosed |
| US-20080319026-A1 | SUBSTITUTED N-ARYL PYRIDINONES | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319026-A1 | SUBSTITUTED N-ARYL PYRIDINONES | COL1A1, COL2A1, COLGALT1 | ALDH1A1 293/4885KDM4E 916/4885CYP1A2 97/4885 |
| US-20110313004-A1 | DEUTERATED PYRIDINONES | TNF, TGFB1, PDXK | ALDH1A1 1952/4885KDM4E 1483/4885CYP1A2 1753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.