SCHEMBL33659

SCHEMBL33659

Cc1cc(N)ccc1NC(C)O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.46
SIGMAR1 Q99720 3/20 0.46
CYP1A2 P05177 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
PDE10A Q9Y233 1/20 0.45
ALDH1A1 P00352 4/20 0.45
RAD52 P43351 1/20 0.41
CASP1 P29466 2/20 0.41
TSHR P16473 1/20 0.41
TNIK Q9UKE5 2/20 0.38
GRIN2D O15399 2/20 0.36
GRIN3B O60391 2/20 0.36
GRIN1 Q05586 2/20 0.36
GRIN2A Q12879 2/20 0.36
GRIN2B Q13224 2/20 0.36
GRIN2C Q14957 2/20 0.36
GRIN3A Q8TCU5 2/20 0.36
CYP3A4 P08684 1/20 0.36
MEN1 O00255 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9464296 0.85 CASP1 (0.45) MAPTSIGMAR1CYP1A2CYP2C9CYP2C19
SCHEMBL8370672 0.84 ALDH1A1 (0.48) MAPTSIGMAR1CYP1A2CYP2C9CYP2C19
SCHEMBL4862775 0.80 SIGMAR1 (0.43) MAPTSIGMAR1CYP1A2CYP2C9CYP2C19
SCHEMBL10050770 0.80 MEN1 (0.48) MAPTALDH1A1MEN1KMT2AL3MBTL1
SCHEMBL20664230 0.79 ALDH1A1 (0.43) MAPTSIGMAR1CYP1A2CYP2C9CYP2C19
SCHEMBL6515938 0.78 KDM4E (0.45) MAPTALDH1A1CASP1TSHRTNIK
SCHEMBL3859936 0.78 SIGMAR1 (0.44) MAPTSIGMAR1CYP1A2CYP2C9CYP2C19
SCHEMBL4862013 0.78 SIGMAR1 (0.41) MAPTSIGMAR1CYP1A2CYP2C9CYP2C19
SCHEMBL5707664 0.77 PDE10A (0.45) MAPTCYP2C9CYP2C19PDE10AALDH1A1
Hydrochloric Acid SCHEMBL3859541 0.77 MAPT (0.43) MAPTSIGMAR1CYP1A2CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1058 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11555017-B2 Oxidation base derived from 1-hexyl-4,5-diaminopyrazole, composition containing same and use thereof in oxidation dyeing of keratin fibres L'OREAL (FR) 2023-01-17 US claimed
US-20200392088-A1 NOVEL OXIDATION BASE DERIVED FROM 1-HEXYL-4,5- DIAMINOPYRAZOLE, COMPOSITION CONTAINING SAME AND USE THEREOF IN OXIDATION DYEING OF KERATIN FIBRES L'OREAL (FR) 2020-12-17 US claimed
EP-3464247-B1 NOVEL OXIDATION BASE DERIVED FROM 1-HEXYL-4,5- DIAMINOPYRAZOLE, COMPOSITION CONTAINING SAME AND USE THEREOF IN OXIDATION DYEING OF KERATIN FIBRES OREAL (FR) 2020-03-11 EP claimed
US-8002847-B2 Composition for oxidation dyeing keratin fibres comprising a cationic cellulose ether, a weakly oxyethylenated sorbitan fatty acid ester and oxidation dyes L 'OREAL S.A. (FR) 2011-08-23 US claimed
US-20100275388-A1 COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC CELLULOSE ETHER, A WEAKLY OXYETHYLENATED SORBITAN FATTY ACID ESTER AND OXIDATION DYES L'OREAL S.A. (FR) 2010-11-04 US claimed
EP-2182914-A2 COMPOSITION OXIDATION COLOURING OF KERATINIC FIBRES, CONTAINING A CATIONIC CELLULOSE ETHER, A METASILICATE AND OXIDATION DYES, METHOD FOR OXIDATION COLOURING AND USES THEREOF L'Oreal (FR) 2010-05-12 EP claimed
EP-2175830-A2 COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC CELLULOSE ETHER, A WEAKLY OXYETHYLENATED SORBITAN FATTY ACID ESTER AND OXIDATION DYES L'Oreal (FR) 2010-04-21 EP claimed
EP-1319393-B1 Composition for dyeing keratin fibres with an alcohol oxidase and process for applying this composition OREAL (FR) 2009-09-02 EP claimed
WO-2009019383-A2 COMPOSITION OXIDATION COLOURING OF KERATINIC FIBRES, CONTAINING A CATIONIC CELLULOSE ETHER, A METASILICATE AND OXIDATION DYES, METHOD FOR OXIDATION COLOURING AND USES THEREOF L'OREAL (FR) 2009-02-12 WO claimed
WO-2009016061-A2 COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC CELLULOSE ETHER, A WEAKLY OXYETHYLENATED SORBITAN FATTY ACID ESTER AND OXIDATION DYES L'OREAL (FR) 2009-02-05 WO claimed
US-7282067-B2 Composition for dyeing keratin fibres, containing an alcohol oxidase, and process using this composition L'OREAL (FR) 2007-10-16 US claimed
US-20060000033-A1 Dyeing composition comprising at least one elastomeric film-forming polymer and at least one oxidation dye precursor L'OREAL S.A. (FR) 2006-01-05 US claimed
US-20040154109-A1 Composition for dyeing keratin fibers, comprising at least one dialdehyde heterocyclic compound and at least one nitrogen compound L'OREAL S.A. (FR) 2004-08-12 US claimed
US-20030154563-A1 Composition for dyeing keratin fibres, containing an alcohol oxidase, and process using this composition L'OREAL (FR) 2003-08-21 US claimed
WO-2026102602-A1 COMPOSITION FOR DYEING KERATIN FIBERS L'OREAL (FR) 2026-05-21 WO disclosed
WO-2026102601-A1 COMPOSITION FOR DYEING KERATIN FIBERS L'OREAL (FR) 2026-05-21 WO disclosed
EP-4673111-A1 COLORANT COMPOSITION FOR DYEING KERATIN FIBERS AND DYE KIT CONTAINING THE SAME L'OREAL (FR) 2026-01-07 EP disclosed
WO-2003039500-A1 USE OF A MERTENSIA MARITIMA EXTRACT IN OXIDATION DYEING OF KERATINOUS FIBERS L'OREAL (FR) 2003-05-15 WO disclosed
WO-2002076419-A1 OXIDATION DYEING COMPOSITION CONTAINING 3-AMINO PYRAZOLO-[1,5-A]-PYRIDINE AND ONE AMINOPHENOL COUPLING AGENT L'OREAL (FR) 2002-10-03 WO disclosed
WO-2002074269-A2 DYEING COMPOSITIONS FOR KERATIN FIBRES CONTAINING PARAPHENYLENEDIAMINE DERIVATIVES WITH PYRROLIDINYL GROUP L'OREAL (FR) 2002-09-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030154563-A1 Composition for dyeing keratin fibres, containing an alcohol oxidase, and process using this composition KRT18, ADH5, ADH1C MAPT 413/4885SIGMAR1 4349/4885CYP1A2 260/4885
US-20200392088-A1 NOVEL OXIDATION BASE DERIVED FROM 1-HEXYL-4,5- DIAMINOPYRAZOLE, COMPOSITION CONTAINING SAME AND USE THEREOF IN OXIDATION DYEING OF KERATIN FIBRES KRT18, ALK, AOC1 MAPT 148/4885SIGMAR1 3363/4885CYP1A2 1241/4885
US-20100275388-A1 COMPOSITION FOR OXIDATION DYEING KERATIN FIBRES COMPRISING A CATIONIC CELLULOSE ETHER, A WEAKLY OXYETHYLENATED SORBITAN FATTY ACID ESTER AND OXIDATION DYES KRT18, KRTCAP2, FASN MAPT 687/4885SIGMAR1 2907/4885CYP1A2 1251/4885
US-20040154109-A1 Composition for dyeing keratin fibers, comprising at least one dialdehyde heterocyclic compound and at least one nitrogen compound KRT18, KRTCAP2, KLK5 MAPT 636/4885SIGMAR1 4114/4885CYP1A2 2327/4885
US-20060000033-A1 Dyeing composition comprising at least one elastomeric film-forming polymer and at least one oxidation dye precursor RAD50, IK, RAD51 MAPT 696/4885SIGMAR1 1069/4885CYP1A2 1398/4885
US-11555017-B2 Oxidation base derived from 1-hexyl-4,5-diaminopyrazole, composition containing same and use thereof in oxidation dyeing of keratin fibres KRT18, ALK, AOC1 MAPT 169/4885SIGMAR1 3102/4885CYP1A2 922/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.