Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorene SCHEMBL28315043 | 0.77 | TSHR (0.53) | TSHRALDH1A1DRD2SIGMAR1ADRA1D | |
| Hydrochloric Acid SCHEMBL3369280 | 0.73 | CYSLTR2 (0.36) | DRD2DRD4DRD3SIGMAR1ALOX12 | |
| SCHEMBL7934235 | 0.70 | DRD2 (0.43) | ALDH1A1DRD2DRD4DRD3ADRA1D | |
| SCHEMBL14917364 | 0.69 | TSHR (0.52) | TSHRALDH1A1SIGMAR1HTR1A | |
| SCHEMBL9162757 | 0.68 | DRD2 (0.44) | ALDH1A1DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL27389420 | 0.68 | PTGS2 (0.42) | SIGMAR1 | |
| Fluorene SCHEMBL25291666 | 0.67 | MAOA (0.50) | TSHRALDH1A1DRD2SIGMAR1ALOX12 | |
| SCHEMBL2416249 | 0.67 | LIPG (0.44) | ALDH1A1DRD2DRD4DRD3 | |
| SCHEMBL29508750 | 0.66 | LIPG (0.46) | ALDH1A1DRD2DRD4DRD3 | |
| SCHEMBL28975089 | 0.66 | LIPG (0.46) | ALDH1A1DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6232415-B1 | Process to produce a monovinylaromatic/ monoolefin polymer and said monovinylaromatic/monoolefin polymer | PHILLIPS PETROLEUM COMPANY | 2001-05-15 | — | — | US | claimed |
| EP-0853549-B1 | FILMS COMPRISING METALLOCENE CATALYZED POLYETHYLENE | CHEVRON PHILLIPS CHEMICAL CO (US) | 2010-10-13 | — | — | EP | disclosed |
| US-6355359-B1 | CLARITY | PHILLIPS PETROLEUM COMPANY | 2002-03-12 | — | — | US | disclosed |
| US-6214469-B1 | Films comprising metallocene catalyzed polyethylene | PHILLIPS PETROLEUM COMPANY | 2001-04-10 | — | — | US | disclosed |
| EP-0853549-A4 | FILMS COMPRISING METALLOCENE CATALYZED POLYETHYLENE | PHILLIPS PETROLEUM CO (US) | 1999-08-18 | — | — | EP | disclosed |
| EP-0853549-A1 | FILMS COMPRISING METALLOCENE CATALYZED POLYETHYLENE | Phillips Petroleum Company (US) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997006951-A1 | FILMS COMPRISING METALLOCENE CATALYZED POLYETHYLENE | PHILLIPS PETROLEUM COMPANY (US) | 1997-02-27 | — | — | WO | disclosed |