Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.39 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL338508 | 0.87 | SGMS2 (0.51) | KMT2AALDH1A1SGMS2 | |
| SCHEMBL338440 | 0.85 | SMN1; SMN2 (0.42) | NPC1BRD4KMT2ATAOK1TAOK3 | |
| SCHEMBL339330 | 0.84 | MEN1 (0.43) | NPC1BRD4KMT2ATDP1TAOK1 | |
| SCHEMBL338492 | 0.84 | NOTUM (0.42) | NPC1KMT2ATDP1ALDH1A1LMNA | |
| SCHEMBL339469 | 0.83 | RIPK1 (0.44) | RIPK1BRD4KMT2AALDH1A1SGMS2 | |
| SCHEMBL338604 | 0.82 | NAAA (0.41) | NPC1KMT2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL339628 | 0.79 | BRD4 (0.38) | NPC1BRD4KMT2ATDP1ALDH1A1 | |
| SCHEMBL338050 | 0.78 | RIPK1 (0.45) | RIPK1NPC1KMT2ATDP1MMP13 | |
| SCHEMBL338637 | 0.76 | KDM1A (0.42) | NPC1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL339010 | 0.75 | ALDH1A1 (0.49) | NPC1KMT2AALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687298-B1 | CYCLOALKYL DERIVATIVES OF 3-HYDROXY-4-PYRIDINONES | APOTEX INC (CA) | 2012-12-26 | — | — | EP | disclosed |
| EP-1824823-B1 | PROCESS FOR THE MANUFACTURE OF 3-HYDROXY-N-ALKYL-1-CYCLOALKYL-6-ALKYL-4-OXO-1,4-DIHYDROPYRIDINE-2-CARBOXAMIDE AND ITS RELATED ANALOGUES | APOTEX INC (CA) | 2012-04-25 | — | — | EP | disclosed |
| EP-1824823-B1 | PROCESS FOR THE MANUFACTURE OF 3-HYDROXY-N-ALKYL-1-CYCLOALKYL-6-ALKYL-4-OXO-1,4-DIHYDROPYRIDINE-2-CARBOXAMIDE AND ITS RELATED ANALOGUES | APOTEX INC (CA) | 2012-04-25 | — | — | EP | disclosed |
| US-8097624-B2 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones | APOTEX INC. (CA) | 2012-01-17 | — | — | US | disclosed |
| US-7893269-B2 | amidation of 3-(benzyloxy)-1-cyclopropyl-6-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid via the 2-acid chloride and then reaction with an amine; hydrolysis or catalytic hydrogenation to deprotect 3-hydroxy group; high yields for industrial application; the 3-(benzyloxy)-2-carboxamide intermediate | APOTEX INC (CA) | 2011-02-22 | — | — | US | disclosed |
| US-7893269-B2 | amidation of 3-(benzyloxy)-1-cyclopropyl-6-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid via the 2-acid chloride and then reaction with an amine; hydrolysis or catalytic hydrogenation to deprotect 3-hydroxy group; high yields for industrial application; the 3-(benzyloxy)-2-carboxamide intermediate | APOTEX INC (CA) | 2011-02-22 | — | — | US | disclosed |
| US-7893269-B2 | amidation of 3-(benzyloxy)-1-cyclopropyl-6-methyl-4-oxo-1,4-dihydropyridine-2-carboxylic acid via the 2-acid chloride and then reaction with an amine; hydrolysis or catalytic hydrogenation to deprotect 3-hydroxy group; high yields for industrial application; the 3-(benzyloxy)-2-carboxamide intermediate | APOTEX INC (CA) | 2011-02-22 | — | — | US | disclosed |
| US-20090170850-A1 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones | APOTEX INC. | 2009-07-02 | — | — | US | disclosed |
| CN-100448873-C | Cycloalkyl derivatives of 3-hydroxy-4-pyridones | APOTEX INC (CA) | 2009-01-07 | — | — | CN | disclosed |
| US-7410985-B2 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones | APOTEX INC. (CA) | 2008-08-12 | — | — | US | disclosed |
| US-20080096886-A1 | Process For The Manufacture Of 3-Hydroxy-N-Alkyl-1-Cycloalkyl-6-Alkyl-4-Oxo-1,4-Dihydropyridine-2-Carboxamide And Its Related Analogues | APOTEX INC. (CA) | 2008-04-24 | — | — | US | disclosed |
| US-20080096886-A1 | Process For The Manufacture Of 3-Hydroxy-N-Alkyl-1-Cycloalkyl-6-Alkyl-4-Oxo-1,4-Dihydropyridine-2-Carboxamide And Its Related Analogues | APOTEX INC. (CA) | 2008-04-24 | — | — | US | disclosed |
| US-20080096886-A1 | Process For The Manufacture Of 3-Hydroxy-N-Alkyl-1-Cycloalkyl-6-Alkyl-4-Oxo-1,4-Dihydropyridine-2-Carboxamide And Its Related Analogues | APOTEX INC. (CA) | 2008-04-24 | — | — | US | disclosed |
| CN-1926135-A | Cycloalkyl derivatives of 3-hydroxy-4-pyridones | APOTEX INC (CA) | 2007-03-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170850-A1 | Cycloalkyl derivatives of 3-hydroxy-4-pyridinones | HAMP, C1S, C1R | RIPK1 4240/4885NPC1 1751/4885BRD4 2077/4885 |
| US-20080096886-A1 | Process For The Manufacture Of 3-Hydroxy-N-Alkyl-1-Cycloalkyl-6-Alkyl-4-Oxo-1,4-Dihydropyridine-2-Carboxamide And Its Related Analogues | ADH1C, ADH1A, ADH5 | RIPK1 3813/4885NPC1 4610/4885BRD4 3241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.