Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | ACP3 | P15309 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | P4HB | P07237 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3151486 | 0.86 | MAOA (0.49) | ALDH1A1 | |
| SCHEMBL67201 | 0.86 | FBP1 (0.56) | FBP1POLBALDH1A1L3MBTL1NFE2L2 | |
| SCHEMBL29425705 | 0.86 | FBP1 (0.56) | FBP1POLBALDH1A1L3MBTL1NFE2L2 | |
| SCHEMBL18001841 | 0.85 | DAO (0.49) | FBP1POLBALDH1A1L3MBTL1ACP3 | |
| SCHEMBL30644998 | 0.85 | DAO (0.49) | FBP1POLBALDH1A1L3MBTL1ACP3 | |
| SCHEMBL18002752 | 0.81 | IDO1 (0.55) | POLBALDH1A1L3MBTL1ACP3TAAR1 | |
| Acetaldehyde SCHEMBL28151033 | 0.81 | NFE2L2 (0.54) | FBP1POLBALDH1A1L3MBTL1NFE2L2 | |
| SCHEMBL3643679 | 0.80 | TAAR1 (0.62) | ALDH1A1ACP3TAAR1MAPTIDO1 | |
| SCHEMBL18002652 | 0.80 | NFE2L2 (0.62) | FBP1POLBALDH1A1L3MBTL1NFE2L2 | |
| Phenethylamine SCHEMBL7800077 | 0.79 | TAAR1 (0.62) | FBP1TAAR1IDO1HTR2AGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8318787-B2 | Prodrugs of (3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-C]oxazol-7A-yl)methanol and derivatives thereof | UNIVERSITY OF KANSAS (US) | 2012-11-27 | — | — | US | disclosed |
| US-20100056592-A1 | PRODRUGS OF (3,5-BIS(4-FLUOROPHENYL)TETRAHYDRO-1H-OXAZOLO[3,4-C]OXAZOL-7A-YL)METHANOL AND DERIVATIVES THEREOF | UNIVERSITY OF KANSAS | 2010-03-04 | — | — | US | disclosed |
| US-7598282-B2 | (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-1H-oxazolo[3,4-c]oxazol-7a-yl)methanol; does not involve microtubule stabilization; Alzheimer's | UNIVERSITY OF KANSAS (US) | 2009-10-06 | — | — | US | disclosed |
| WO-2007053684-A2 | NEUROPROTECTIVE AGENTS | UNIVERSITY OF KANSAS (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20070099971-A1 | Neuroprotective agents | UNIVERSITY OF KANSAS | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056592-A1 | PRODRUGS OF (3,5-BIS(4-FLUOROPHENYL)TETRAHYDRO-1H-OXAZOLO[3,4-C]OXAZOL-7A-YL)METHANOL AND DERIVATIVES THEREOF | OXA1L, ADH1A, ADH1C | FBP1 1703/4885POLB 546/4885ALDH1A1 10/4885 |
| US-20070099971-A1 | Neuroprotective agents | MAP4, MAP1LC3A, TUBB4A | FBP1 3455/4885POLB 3036/4885ALDH1A1 1371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.