Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | BLVRB | P30043 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | RAD1 | O60671 | 1/20 | 0.40 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9064961 | 0.84 | MEN1 (0.48) | TSHRSMN1; SMN2TDP1HSD17B10ALDH1A1 | |
| SCHEMBL1498097 | 0.83 | TSHR (0.61) | TSHRCASP1SMN1; SMN2TDP1MAPK1 | |
| SCHEMBL1498095 | 0.83 | TSHR (0.61) | TSHRCASP1SMN1; SMN2TDP1MAPK1 | |
| SCHEMBL9430351 | 0.81 | ALDH1A1 (0.43) | SMN1; SMN2TDP1MAPK1HSD17B10ALDH1A1 | |
| SCHEMBL1483825 | 0.81 | ABL1 (0.43) | CASP1SMN1; SMN2TDP1MAPK1HSD17B10 | |
| SCHEMBL3399131 | 0.81 | ALDH1A1 (0.50) | TSHRTDP1MAPK1HSD17B10ALDH1A1 | |
| SCHEMBL15391204 | 0.79 | HSD17B10 (0.41) | TDP1HSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL25393567 | 0.79 | RAB9A (0.46) | SMN1; SMN2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL3395948 | 0.77 | MEN1 (0.70) | TSHRCASP1SMN1; SMN2TDP1HSD17B10 | |
| SCHEMBL22597915 | 0.76 | MEN1 (0.44) | TDP1HSD17B10ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9102602-B2 | Method for producing isothiocyanate compound | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2015-08-11 | — | — | US | disclosed |
| US-9102602-B2 | Method for producing isothiocyanate compound | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2015-08-11 | — | — | US | disclosed |
| US-9102602-B2 | Method for producing isothiocyanate compound | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2015-08-11 | — | — | US | disclosed |
| CN-101965331-B | Method for producing isothiocyanate compound having carboxyl group | NISSAN CHEMICAL IND LTD | 2014-04-16 | — | — | CN | disclosed |
| EP-2647623-A1 | METHOD FOR PRODUCING ISOTHIOCYANATE COMPOUND | Nissan Chemical Industries, Ltd. (JP) | 2013-10-09 | — | — | EP | disclosed |
| EP-2647623-A1 | METHOD FOR PRODUCING ISOTHIOCYANATE COMPOUND | Nissan Chemical Industries, Ltd. (JP) | 2013-10-09 | — | — | EP | disclosed |
| US-20130245305-A1 | METHOD FOR PRODUCING ISOTHIOCYANATE COMPOUND | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-09-19 | — | — | US | disclosed |
| US-20130245305-A1 | METHOD FOR PRODUCING ISOTHIOCYANATE COMPOUND | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-09-19 | — | — | US | disclosed |
| US-20130245305-A1 | METHOD FOR PRODUCING ISOTHIOCYANATE COMPOUND | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-09-19 | — | — | US | disclosed |
| US-8367857-B2 | Method for producing isothiocyanate compound having carboxyl group | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2013-02-05 | — | — | US | disclosed |
| CN-101965331-A | Method for producing isothiocyanate compound having carboxyl group | NISSAN CHEMICAL IND LTD | 2011-02-02 | — | — | CN | disclosed |
| US-20100312000-A1 | METHOD FOR PRODUCING ISOTHIOCYANATE COMPOUND HAVING CARBOXYL GROUP | NISSAN CHEMICAL INDUSTRIES LIMITED (JP) | 2010-12-09 | — | — | US | disclosed |
| EP-2248800-A1 | METHOD FOR PRODUCING ISOTHIOCYANATE COMPOUND HAVING CARBOXYL GROUP | Nissan Chemical Industries, Ltd. (JP) | 2010-11-10 | — | — | EP | disclosed |
| EP-1438046-A4 | THIAZOLE BENZAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING CELL PROLIFERATION, AND METHODS FOR THEIR USE | AGOURON PHARMA (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-1438046-A2 | THIAZOLE BENZAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING CELL PROLIFERATION, AND METHODS FOR THEIR USE | AGOURON PHARMACEUTICALS, INC. (US) | 2004-07-21 | — | — | EP | disclosed |
| US-6720346-B2 | (4-AMINOTHIAZOL-2-YLAMINO)-BENZAMIDE COMPOUNDS; PROTEIN KINASE INHIBITORS; CANCER; AUTOIMMUNE, VIRAL, FUNGAL, NEURODEGENERATIVE, AND CARDIOVASCULAR DISORDERS | AGOURON PHARMACEUTICALS, INC. | 2004-04-13 | — | — | US | disclosed |
| US-20030225147-A1 | Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation, and methods for their use | AGOURON PHARMACEUTICALS INC. | 2003-12-04 | — | — | US | disclosed |
| WO-2003004467-A2 | THIAZOLE BENZAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING CELL PROLIFERATION, AND METHODS FOR THEIR USE | AGOURON PHARMACEUTICALS, INC. (US) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225147-A1 | Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation, and methods for their use | TK1, MKI67, CDKN1A | TSHR 2198/4885CASP1 318/4885SMN1; SMN2 3198/4885 |
| US-20100312000-A1 | METHOD FOR PRODUCING ISOTHIOCYANATE COMPOUND HAVING CARBOXYL GROUP | CBS, CTH, TST | TSHR 2373/4885CASP1 2567/4885SMN1; SMN2 4665/4885 |
| US-20130245305-A1 | METHOD FOR PRODUCING ISOTHIOCYANATE COMPOUND | TST, CTH, ICMT | TSHR 2627/4885CASP1 2523/4885SMN1; SMN2 4842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.