SCHEMBL3400359

SCHEMBL3400359

CC(C)C(N=C=O)C(=O)OC(C)(C)C

nearest known ligand 0.34

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CTSS P25774 1/20 0.34
CTSK P43235 1/20 0.34
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA7 P43166 1/20 0.33
NOS1 P29475 2/20 0.32
NOS3 P29474 1/20 0.32
NOS2 P35228 1/20 0.32
AAK1 Q2M2I8 1/20 0.31
CA12 O43570 1/20 0.30
CA14 Q9ULX7 1/20 0.30
PREP P48147 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3310723 1.00 CTSS (0.34) CTSSCTSKCA1CA2CA7
SCHEMBL3400364 1.00 CTSS (0.34) CTSSCTSKCA1CA2CA7
SCHEMBL12484953 0.87 NOS1 (0.31) CTSSCTSKNOS1NOS3NOS2
SCHEMBL12485083 0.82 CTSS (0.38) CTSSCTSKNOS1NOS3NOS2
SCHEMBL12484364 0.80 NOS1 (0.33) CTSSCTSKCA1CA2CA7
SCHEMBL14968296 0.80 NOS1 (0.33) CTSSCTSKCA1CA2CA7
SCHEMBL24217635 0.80 CYP2D6 (0.37) CTSSCTSKNOS1NOS3NOS2
SCHEMBL15411838 0.78 CTSS (0.32) CTSSCTSKCA1CA2CA7
SCHEMBL28079855 0.78 CTSS (0.32) CTSSCTSKCA1CA2CA7
SCHEMBL1439238 0.78 SMN1; SMN2 (0.41) CA7CA12CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140051706-A1 ALPHA HELIX MIMETICS AND METHODS RELATING THERETO PRISM PHARMA CO., LTD. (JP) 2014-02-20 US disclosed
CN-103517904-A Alpha-helix mimetics and methods relating thereto PRISM BIOLAB CORP 2014-01-15 CN disclosed
EP-2678341-A1 ALPHA HELIX MIMETICS AND METHODS RELATING THERETO PRISM Pharma Co., Ltd. (JP) 2014-01-01 EP disclosed
US-20120270847-A1 NOVEL CARBAMATE AMINO ACID AND PEPTIDE PRODRUGS OF OPIATES AND USES THEREOF SHIRE LLC (US) 2012-10-25 US disclosed
WO-2012115286-A1 ALPHA HELIX MIMETICS AND METHODS RELATING THERETO PRISM BIOLAB CORPORATION (JP) 2012-08-30 WO disclosed
US-20110015182-A1 NOVEL CARBAMATE AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF SHIRE LLC 2011-01-20 US disclosed
US-20110015182-A1 NOVEL CARBAMATE AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF SHIRE LLC 2011-01-20 US disclosed
EP-2250167-A1 ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS Chlorion Pharma, Inc. (CA) 2010-11-17 EP disclosed
US-20100227921-A1 AMINO ACID AND PEPTIDE CARBAMATE PRODRUGS OF TAPENTADOL AND USES THEREOF SHIRE LLC (US) 2010-09-09 US disclosed
US-20090275538-A1 ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS UNIVERSITE LAVAL (CA) 2009-11-05 US disclosed
WO-2009097695-A1 ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS CHLORION PHARMA, INC. (CA) 2009-08-13 WO disclosed
US-20090192095-A1 AMINO ACID AND PEPTIDE PRODRUGS OF OPIOID ANALGESICS WITH REDUCED GI SIDE-EFFECTS SHIRE LLC (US) 2009-07-30 US disclosed
WO-2009092073-A2 AMINO ACID AND PEPTIDE PRODRUGS OF OPIOID ANALGESICS WITH REDUCED GI SIDE-EFFECTS SHIRE LLC (US) 2009-07-23 WO disclosed
US-20090186832-A1 AMINO ACID PEPTIDE PRO-DRUGS OF PHENOLIC ANALGESICS AND USES THEREOF SHIRE LLC (US) 2009-07-23 US disclosed
WO-2009092071-A2 AMINO ACID AND PEPTIDE PRO-DRUGS OF PHENOLIC ANALGESICS AND USES THEREOF SHIRE LLC (US) 2009-07-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090275538-A1 ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS OPRL1, OPRK1, AHR CTSS 1139/4885CTSK 1004/4885CA1 1561/4885
US-20110015182-A1 NOVEL CARBAMATE AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF OPRL1, OPRM1, DNPEP CTSS 718/4885CTSK 660/4885CA1 250/4885
US-20140051706-A1 ALPHA HELIX MIMETICS AND METHODS RELATING THERETO COL1A1, PLOD3, THPO CTSS 1357/4885CTSK 1924/4885CA1 3387/4885
US-20120270847-A1 NOVEL CARBAMATE AMINO ACID AND PEPTIDE PRODRUGS OF OPIATES AND USES THEREOF OPRL1, OPRM1, DNPEP CTSS 709/4885CTSK 615/4885CA1 350/4885
US-20090186832-A1 AMINO ACID PEPTIDE PRO-DRUGS OF PHENOLIC ANALGESICS AND USES THEREOF DNPEP, PEPD, PREP CTSS 1011/4885CTSK 784/4885CA1 925/4885
US-20090192095-A1 AMINO ACID AND PEPTIDE PRODRUGS OF OPIOID ANALGESICS WITH REDUCED GI SIDE-EFFECTS OPRL1, OGFR, OPRK1 CTSS 515/4885CTSK 565/4885CA1 104/4885
US-20100227921-A1 AMINO ACID AND PEPTIDE CARBAMATE PRODRUGS OF TAPENTADOL AND USES THEREOF VIP, DNPEP, PEPD CTSS 455/4885CTSK 450/4885CA1 507/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.