SCHEMBL342382

SCHEMBL342382

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nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GLO1 Q04760 1/20 0.32
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17339986 0.81 TSHR (0.48) ALDH1A1
SCHEMBL6572365 0.79
SCHEMBL16433403 0.76 ALDH1A1 (0.37) GLO1ALDH1A1LMNAHSD17B10
SCHEMBL27654348 0.76 GLO1 (0.36) GLO1ALDH1A1LMNAHSD17B10
SCHEMBL13334145 0.75
SCHEMBL22582940 0.75 ALDH1A1 (0.40) GLO1ALDH1A1LMNAHSD17B10
SCHEMBL27707063 0.74 GLO1 (0.34) GLO1ALDH1A1LMNAHSD17B10
SCHEMBL27823858 0.74 GLO1 (0.34) GLO1ALDH1A1LMNAHSD17B10
SCHEMBL27820684 0.74 GLO1 (0.34) GLO1ALDH1A1LMNAHSD17B10
SCHEMBL3049017 0.74 PAM (0.40) GLO1ALDH1A1LMNAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013078554-A1 COMPOSITIONS OF TIGECYCLINE AND USES THEREOF UNIVERSITY HEALTH NETWORK (CA) 2013-06-06 WO claimed
US-8735633-B2 Methods for making 1,3-dihydroxyacetone (DHA) from glycerol BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) 2014-05-27 US disclosed
CN-103642863-A Method of producing l-amino acid AJINOMOTO KK 2014-03-19 CN disclosed
WO-2014029016-A1 COMPOSITIONS COMPRISING A GLYCYLCYCLINE AND A TYROSINE KINASE INHIBITOR FOR TREATING CANCER UNIVERSITY HEALTH NETWORK (CA) 2014-02-27 WO disclosed
CN-101631871-B Process for producing L-amino acid AJINOMOTO KK 2013-09-11 CN disclosed
WO-2013078554-A1 COMPOSITIONS OF TIGECYCLINE AND USES THEREOF UNIVERSITY HEALTH NETWORK (CA) 2013-06-06 WO disclosed
US-20120014889-A1 METHODS FOR MAKING 1,3-DIHYDROXYACETONE (DHA) FROM GLYCEROL BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY 2012-01-19 US disclosed
CN-101631871-A Process for producing L-amino acid AJINOMOTO KK 2010-01-20 CN disclosed
WO-2002102348-A1 ANTI-STRETCH MARK PRODUCT AND CORRESPONDING METHOD PRISCILLA S.R.L. UNIPERSONALE (IT) 2002-12-27 WO disclosed
WO-2002080880-A2 ANTI-STRETCH MARK PREPARATION AND METHOD THEREOF PRISCILLA S.R.L. UNIPERSONALE (IT) 2002-10-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120014889-A1 METHODS FOR MAKING 1,3-DIHYDROXYACETONE (DHA) FROM GLYCEROL DGAT2, ADH1B, ADH1A GLO1 101/4885ALDH1A1 28/4885LMNA 2432/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.