Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAM | P19021 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | THPO | P40225 | 2/20 | 0.39 |
| ▸ | CTH | P32929 | 1/20 | 0.39 |
| ▸ | CBS | P35520 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.33 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6278211 | 0.82 | TSHR (0.47) | PAMTSHRTHPOCTHCBS | |
| SCHEMBL27654348 | 0.80 | GLO1 (0.36) | TSHRTHPOGLO1ALDH1A1LMNA | |
| SCHEMBL75506 | 0.79 | TSHR (0.52) | PAMTSHRTHPOCTHCBS | |
| SCHEMBL27707063 | 0.78 | GLO1 (0.34) | TSHRTHPOGLO1ALDH1A1LMNA | |
| SCHEMBL27823858 | 0.78 | GLO1 (0.34) | TSHRTHPOGLO1ALDH1A1LMNA | |
| SCHEMBL27820684 | 0.78 | GLO1 (0.34) | TSHRTHPOGLO1ALDH1A1LMNA | |
| Ammonia Solution, Strong SCHEMBL9653768 | 0.77 | TSHR (0.50) | PAMTSHRTHPOCTHCBS | |
| Hydrochloric Acid SCHEMBL865705 | 0.77 | TSHR (0.50) | PAMTSHRTHPOCTHCBS | |
| SCHEMBL27931770 | 0.77 | OR51E2 (0.32) | GLO1 | |
| SCHEMBL28447552 | 0.77 | TSHR (0.40) | PAMTSHRTHPOCTHCBS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170239154-A1 | PYRUVATE AND RELATED ALPHA-KETO CARBOXYLATES AS NOVEL ADJUVANTS IN THE TREATMENT OF POST TOOTH WHITENING SENSITIVITY AND THE TISSUE PROTECTIVE EFFECT OF PYRUVATE ON THE ORAL SOFT TISSUE | RUSZNAK ZOLTAN (US) | 2017-08-24 | — | — | US | claimed |
| US-8815946-B2 | Inhibition of proliferation and fibrotic response of activated corneal stromal cells | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2014-08-26 | — | — | US | claimed |
| US-20090239947-A1 | Inhibition of proliferation and fibrotic response of activated corneal stromal cells | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2009-09-24 | — | — | US | claimed |
| EP-1937316-A2 | RADIOPROTECTIVE AGENTS | University of Pittsburgh of the Commonwealth System of Higher Education (US) | 2008-07-02 | — | — | EP | claimed |
| EP-1635806-B1 | METHOD FOR TREATING ALCOHOLIC HEPATITIS | UNIV PITTSBURGH (US) | 2008-05-28 | — | — | EP | claimed |
| WO-2007014237-A2 | RADIOPROTECTIVE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2007-02-01 | — | — | WO | claimed |
| US-20060223887-A1 | Method for treating acute pancreatitis | UNIVERSITY OF PITTSBURGH- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2006-10-05 | — | — | US | claimed |
| EP-1233767-B1 | PYRUVATE ESTER COMPOSITION AND METHOD OF USE FOR RESUSCITATION AFTER EVENTS OF ISCHEMIA AND REPERFUSION | XANTHUS LIFE SCIENCES INC (CA) | 2006-04-12 | — | — | EP | claimed |
| EP-1635806-A2 | METHOD FOR TREATING ALCOHOLIC HEPATITIS | UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2006-03-22 | — | — | EP | claimed |
| US-20050245609-A1 | Method of using pyruvate and/or its derivatives for the treatment of cytokine-mediated inflammatory conditions | UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2005-11-03 | — | — | US | claimed |
| US-20050059738-A1 | Pyruvate ester composition and method of use for resuscitation after events of ischemia and reperfusion | XANTHUS LIFE SCIENCES, INC. (CA) | 2005-03-17 | — | — | US | claimed |
| US-20050032891-A1 | Method for treating alcoholic hepatitis | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2005-02-10 | — | — | US | claimed |
| EP-1233767-A4 | PYRUVATE ESTER COMPOSITION AND METHOD OF USE FOR RESUSCITATION AFTER EVENTS OF ISCHEMIA AND REPERFUSION | XANTHUS LIFE SCIENCES INC (CA) | 2005-02-09 | — | — | EP | claimed |
| US-6846842-B2 | Pyruvate ester composition and method of use for resuscitation after events of ischemia and reperfusion | BETH ISRAEL DECONESS MEDICAL CENTER, INC. (US) | 2005-01-25 | — | — | US | claimed |
| WO-2005004857-A1 | METHOD FOR TREATING ACUTE PANCREATITIS | UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2005-01-20 | — | — | WO | claimed |
| WO-2005002563-A2 | METHOD FOR TREATING ALCOHOLIC HEPATITIS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCTION (US) | 2005-01-13 | — | — | WO | claimed |
| US-20040110833-A1 | Method of using pyruvate and/or its derivatives for the treatment of cytokine-mediated inflammatory conditions | UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2004-06-10 | — | — | US | claimed |
| US-20030073743-A1 | Pyruvate ester composition and method of use for resuscitation after events of ischemia and reperfusion | XANTHUS LIFE SCIENCES, INC. (CA) | 2003-04-17 | — | — | US | claimed |
| EP-1233767-A1 | PYRUVATE ESTER COMPOSITION AND METHOD OF USE FOR RESUSCITATION AFTER EVENTS OF ISCHEMIA AND REPERFUSION | Xanthus Life Sciences, Inc. (CA) | 2002-08-28 | — | — | EP | claimed |
| WO-2001024793-A1 | PYRUVATE ESTER COMPOSITION AND METHOD OF USE FOR RESUSCITATION AFTER EVENTS OF ISCHEMIA AND REPERFUSION | XANTHUS LIFE SCIENCES, INC. (CA) | 2001-04-12 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223887-A1 | Method for treating acute pancreatitis | PNLIP, LIPA, AMY2A | PAM 351/4885TSHR 2399/4885THPO 1525/4885 |
| US-20050245609-A1 | Method of using pyruvate and/or its derivatives for the treatment of cytokine-mediated inflammatory conditions | IL1B, HMGB2, HMGB1 | PAM 1991/4885TSHR 3340/4885THPO 337/4885 |
| US-20050032891-A1 | Method for treating alcoholic hepatitis | ADH1A, ADH5, FABP1 | PAM 707/4885TSHR 2060/4885THPO 1822/4885 |
| US-20040110833-A1 | Method of using pyruvate and/or its derivatives for the treatment of cytokine-mediated inflammatory conditions | HMGB1, HMGB2, HMGB3 | PAM 1759/4885TSHR 3355/4885THPO 509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.