Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13409098 | 0.85 | PAOX (0.38) | ALDH1A1 | |
| SCHEMBL28332885 | 0.82 | ALDH1A1 (0.36) | ALDH1A1LMNASLC15A2 | |
| SCHEMBL17653600 | 0.78 | CES1 (0.37) | ALDH1A1 | |
| SCHEMBL7994854 | 0.77 | FFAR3 (0.40) | ALDH1A1LMNA | |
| SCHEMBL12176250 | 0.75 | — | — | |
| SCHEMBL12672981 | 0.74 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL3746246 | 0.74 | GPR84 (0.44) | ALDH1A1LMNA | |
| SCHEMBL835135 | 0.74 | CES2 (0.41) | ALDH1A1 | |
| Ethylene Glycol SCHEMBL28276062 | 0.72 | FFAR3 (0.36) | ALDH1A1 | |
| SCHEMBL3108530 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163800-B2 | PKC-activating compounds for the treatment of neurodegenerative diseases | BLANCHETTE ROCKEFELLER NEUROSCIENCES INSTITUTE (US) | 2012-04-24 | — | — | US | disclosed |
| US-20120027687-A1 | FATTY ACID PROTEIN KINASE C ACTIVATORS AND ANTICOAGULANT FOR THE TREATMENT OF STROKE | WEST VIRGINIA UNIVERSITY | 2012-02-02 | — | — | US | disclosed |
| US-20100022645-A1 | PKC-Activating Compounds for the Treatment of Neurodegenerative Diseases | BLANCHETTE ROCKEFELLER NEUROSCIENCES INSTITUTE (US) | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022645-A1 | PKC-Activating Compounds for the Treatment of Neurodegenerative Diseases | PRKCH, PRKCA, PRKCG | ALDH1A1 3269/4885LMNA 1513/4885SLC15A2 4162/4885 |
| US-20120027687-A1 | FATTY ACID PROTEIN KINASE C ACTIVATORS AND ANTICOAGULANT FOR THE TREATMENT OF STROKE | PRKCA, FABP7, PRKCZ | ALDH1A1 3610/4885LMNA 450/4885SLC15A2 4226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.