Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8880835 | 0.81 | KDM4E (0.47) | KDM4EALDH1A1HPGDGABRA1GABRB2 | |
| SCHEMBL8880203 | 0.79 | ALDH1A1 (0.44) | KDM4EALDH1A1HPGDGABRA1GABRB2 | |
| SCHEMBL6906894 | 0.76 | FOLH1 (0.44) | KDM4EALDH1A1HPGDRIPK1ALOX15 | |
| SCHEMBL8879191 | 0.75 | KDM4E (0.40) | KDM4EALDH1A1HPGDHCRTR1HCRTR2 | |
| SCHEMBL28863330 | 0.75 | KDM4E (0.37) | KDM4EALDH1A1HPGDGABRA1GABRB2 | |
| SCHEMBL343948 | 0.75 | FOLH1 (0.43) | KDM4EALDH1A1HPGDRIPK1ALOX15 | |
| Potassium Ion SCHEMBL343519 | 0.73 | TSHR (0.46) | KDM4EALDH1A1HPGD | |
| SCHEMBL3674007 | 0.73 | GABRA1 (0.47) | KDM4EALDH1A1HPGDGABRA1GABRB2 | |
| SCHEMBL1685206 | 0.73 | GABRA1 (0.40) | HPGDGABRA1GABRB2RIPK1ALOX15 | |
| SCHEMBL1275546 | 0.73 | GABRA1 (0.40) | KDM4EALDH1A1HPGDGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120016152-A1 | Process for the preparation of 4`-haloalkylbiphenyl-2-carboxylic acids | SALTIGO GMBH (DE) | 2012-01-19 | — | — | US | disclosed |
| EP-2366680-A2 | Method for manufacturing 4'-halogenalkyl-biphenyl-2-carboxylic acids | Saltigo GmbH (DE) | 2011-09-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120016152-A1 | Process for the preparation of 4`-haloalkylbiphenyl-2-carboxylic acids | CYP4B1, HACL2, UGT1A4 | GABRA1 238/4885GABRB2 137/4885KDM4E 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.