SCHEMBL3440495

SCHEMBL3440495

COc1ccc(C=CC(=O)c2ccc(OCC(O)CNC(C)(C)C)cc2)cc1OC

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.64
LMNA P02545 3/20 0.64
KDM4E B2RXH2 2/20 0.64
TNFRSF1A P19438 2/20 0.60
ABCG2 Q9UNQ0 7/20 0.59
MEN1 O00255 2/20 0.59
KMT2A Q03164 2/20 0.59
CA1 P00915 1/20 0.54
CA2 P00918 1/20 0.54
ABCC1 P33527 1/20 0.53
ATM Q13315 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
CYP1A1 P04798 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2D6 P10635 1/20 0.51
CYP1B1 Q16678 1/20 0.51
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
CXCL12 P48061 1/20 0.50
ALDH1A1 P00352 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30383352 1.00 MAPT (0.64) MAPTLMNAKDM4ETNFRSF1AABCG2
SCHEMBL3440494 1.00 MAPT (0.64) MAPTLMNAKDM4ETNFRSF1AABCG2
SCHEMBL3440612 0.89 MAOB (0.60) MAPTLMNATNFRSF1AMEN1KMT2A
SCHEMBL3440610 0.89 MAOB (0.60) MAPTLMNATNFRSF1AMEN1KMT2A
SCHEMBL25191754 0.83 CYP2D6 (0.63) MAPTABCG2KMT2ACYP2D6NPC1
SCHEMBL8675291 0.83 FDPS (0.61) KDM4EMEN1KMT2AALDH1A1
SCHEMBL29426332 0.83 FDPS (0.61) KDM4EMEN1KMT2AALDH1A1
SCHEMBL3440506 0.82 ADRB2 (0.59) MAPTKDM4EABCG2MEN1KMT2A
SCHEMBL3440507 0.82 ADRB2 (0.59) MAPTKDM4EABCG2MEN1KMT2A
SCHEMBL7682835 0.81 NFE2L2 (0.54) MAPTKDM4EABCG2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7807712-B2 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents PRATAP RAM 2010-10-05 US claimed
US-20060142303-A1 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents PRATAP RAM 2006-06-29 US claimed
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed
US-7807712-B2 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents PRATAP RAM 2010-10-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAPT 3297/4885LMNA 1180/4885KDM4E 1732/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAPT 3512/4885LMNA 1817/4885KDM4E 2652/4885
US-20060142303-A1 Oxy substituted chalcones as antihyperglycemic and antidyslipidemic agents LIPC, CYP46A1, HMGCR MAPT 4801/4885LMNA 2229/4885KDM4E 653/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAPT 3512/4885LMNA 1817/4885KDM4E 2652/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.