Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | CTSE | P14091 | 1/20 | 0.33 |
| ▸ | PGC | P20142 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3441527 | 0.83 | TAAR1 (0.37) | ALDH1A1SLC6A4 | |
| SCHEMBL3441576 | 0.81 | ADRA2A (0.42) | ADRA2A | |
| SCHEMBL3441782 | 0.81 | ADRA2A (0.42) | ADRA2A | |
| SCHEMBL3441577 | 0.81 | ADRA2A (0.42) | ADRA2A | |
| SCHEMBL6954690 | 0.73 | SLC6A2 (0.41) | ADRA2ACYP3A4CYP2D6CYP2C9SLC6A2 | |
| SCHEMBL7805384 | 0.69 | HTR3A (0.39) | RENCYP3A4CYP2D6CYP2C9SLC6A2 | |
| SCHEMBL11547375 | 0.68 | SLC6A3 (0.44) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3914733 | 0.67 | SLC6A4 (0.50) | ALDH1A1RENCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4161319 | 0.66 | MLNR (0.36) | REN | |
| Hydrochloric Acid SCHEMBL29090963 | 0.66 | SLC6A4 (0.49) | ALDH1A1RENCYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7812047-B2 | 4-imidazolines | HOFFMAN-LA ROCHE INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-7812047-B2 | 4-imidazolines | HOFFMAN-LA ROCHE INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-7812047-B2 | 4-imidazolines | HOFFMAN-LA ROCHE INC. (US) | 2010-10-12 | — | — | US | disclosed |
| EP-2173719-A1 | 4-IMIDAZOLINES AND THEIR USE AS ANTIDEPRESSANTS | F. Hoffmann-Roche AG (CH) | 2010-04-14 | — | — | EP | disclosed |
| CN-101687811-A | 4-imidazolines and as the application of antidepressive | HOFFMANN LA ROCHE | 2010-03-31 | — | — | CN | disclosed |
| US-20090012138-A1 | 4-IMIDAZOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-08 | — | — | US | disclosed |
| US-20090012138-A1 | 4-IMIDAZOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-08 | — | — | US | disclosed |
| US-20090012138-A1 | 4-IMIDAZOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-08 | — | — | US | disclosed |
| WO-2009003867-A1 | 4-IMIDAZOLINES AND THEIR USE AS ANTIDEPRESSANTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012138-A1 | 4-IMIDAZOLINES | TAAR1, TAAR5, GPR119 | CMA1 2462/4885ADRA2A 69/4885ALDH1A1 612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.