Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | GPR3 | P46089 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | GABRP | O00591 | 3/20 | 0.47 |
| ▸ | GABRD | O14764 | 3/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.47 |
| ▸ | GABRE | P78334 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20200673 | 0.86 | KIF11 (0.47) | KIF11HTTALDH1A1HSD17B10GPR3 | |
| SCHEMBL3197265 | 0.85 | RAB9A (0.53) | KIF11ALDH1A1HSD17B10GPR3MAPT | |
| SCHEMBL9514812 | 0.80 | MAPT (0.53) | KIF11HTTALDH1A1HSD17B10GPR3 | |
| SCHEMBL12855209 | 0.80 | CYP3A4 (0.62) | KIF11HTTALDH1A1HSD17B10GPR3 | |
| SCHEMBL7151023 | 0.80 | CHEK1 (0.46) | KIF11HTTALDH1A1HSD17B10MEN1 | |
| SCHEMBL9653404 | 0.79 | KIF11 (0.47) | KIF11HTTALDH1A1HSD17B10GPR3 | |
| SCHEMBL1026408 | 0.79 | MAPT (0.48) | KIF11HTTALDH1A1HSD17B10GPR3 | |
| SCHEMBL11309637 | 0.78 | MAPT (0.51) | KIF11HTTALDH1A1HSD17B10GPR3 | |
| SCHEMBL3189571 | 0.78 | KIF11 (0.59) | KIF11ALDH1A1HSD17B10GPR3MEN1 | |
| SCHEMBL3202953 | 0.77 | GABRP (0.53) | KIF11HTTALDH1A1HSD17B10GPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2694057-B1 | LIPOXYGENASE INHIBITORS | STANFORD RES INST INT (US) | 2019-06-05 | — | — | EP | claimed |
| US-10646471-B2 | Lipoxygenase inhibitors | SRI INTERNATIONAL (US) | 2020-05-12 | — | — | US | disclosed |
| EP-2694057-B1 | LIPOXYGENASE INHIBITORS | STANFORD RES INST INT (US) | 2019-06-05 | — | — | EP | disclosed |
| US-20170095450-A1 | Lipoxygenase Inhibitors | SRI INTERNATIONAL | 2017-04-06 | — | — | US | disclosed |
| EP-2326327-B1 | ANALOGS OF INDOLE-3-CARBINOL AND THEIR USE AS AGENTS AGAINST INFECTION | STANFORD RES INST INT (US) | 2016-03-23 | — | — | EP | disclosed |
| EP-2326327-B1 | ANALOGS OF INDOLE-3-CARBINOL AND THEIR USE AS AGENTS AGAINST INFECTION | STANFORD RES INST INT (US) | 2016-03-23 | — | — | EP | disclosed |
| EP-2694057-A1 | LIPOXYGENASE INHIBITORS | SRI International (US) | 2014-02-12 | — | — | EP | disclosed |
| US-20130345214-A1 | Lipoxygenase Inhibitors | SRI INTERNATIONAL, INC. (US) | 2013-12-26 | — | — | US | disclosed |
| US-8399502-B2 | Analogs of indole-3-carbinol and their use as agents against infection | SRI INTERNATIONAL (US) | 2013-03-19 | — | — | US | disclosed |
| US-8399502-B2 | Analogs of indole-3-carbinol and their use as agents against infection | SRI INTERNATIONAL (US) | 2013-03-19 | — | — | US | disclosed |
| US-8399502-B2 | Analogs of indole-3-carbinol and their use as agents against infection | SRI INTERNATIONAL (US) | 2013-03-19 | — | — | US | disclosed |
| US-20120283240-A1 | Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection | SRI INTERNATIONAL | 2012-11-08 | — | — | US | disclosed |
| US-20120283240-A1 | Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection | SRI INTERNATIONAL | 2012-11-08 | — | — | US | disclosed |
| US-20120283240-A1 | Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection | SRI INTERNATIONAL | 2012-11-08 | — | — | US | disclosed |
| WO-2012135133-A1 | LIPOXYGENASE INHIBITORS | SRI INTERNATIONAL (US) | 2012-10-04 | — | — | WO | disclosed |
| US-8278341-B2 | Analogs of indole-3-carbinol and their use as agents against infection | SRI INTERNATIONAL (US) | 2012-10-02 | — | — | US | disclosed |
| US-8278341-B2 | Analogs of indole-3-carbinol and their use as agents against infection | SRI INTERNATIONAL (US) | 2012-10-02 | — | — | US | disclosed |
| US-20100069355-A1 | Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection | UNITED STATES GOVERNMENT; DEFENSE THREAT REDUCTION AGENCY | 2010-03-18 | — | — | US | disclosed |
| US-20100069355-A1 | Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection | UNITED STATES GOVERNMENT; DEFENSE THREAT REDUCTION AGENCY | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170095450-A1 | Lipoxygenase Inhibitors | ALOX15B, ALOX12, ALOX15 | KIF11 4816/4885HTT 303/4885ALDH1A1 608/4885 |
| US-20120283240-A1 | Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection | IDO1, IDO2, TDO2 | KIF11 4046/4885HTT 3126/4885ALDH1A1 1789/4885 |
| US-20100069355-A1 | Analogs of Indole-3-Carbinol and Their Use as Agents Against Infection | IDO1, IDO2, TDO2 | KIF11 4046/4885HTT 3126/4885ALDH1A1 1789/4885 |
| US-20130345214-A1 | Lipoxygenase Inhibitors | ALOX15B, ALOX12, ALOX15 | KIF11 4816/4885HTT 303/4885ALDH1A1 608/4885 |
| US-10646471-B2 | Lipoxygenase inhibitors | ALOX15B, ALOX12, ALOX15 | KIF11 4816/4885HTT 303/4885ALDH1A1 608/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.