Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 11/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | HPGD | P15428 | 4/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.70 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.70 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.70 |
| ▸ | BLM | P54132 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.65 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | GRM8 | O00222 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10723439 | 1.00 | TDP1 (0.70) | TDP1KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL449665 | 1.00 | TDP1 (0.70) | TDP1KDM4EHSD17B10ALDH1A1HPGD | |
| Bromide SCHEMBL11670638 | 0.98 | TDP1 (0.68) | TDP1KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL10721569 | 0.83 | TDP1 (0.55) | TDP1KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL11926758 | 0.83 | TDP1 (0.55) | TDP1KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL12648648 | 0.82 | HSD17B10 (1.00) | TDP1KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL20522819 | 0.82 | HSD17B10 (0.64) | TDP1KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL20693801 | 0.82 | HSD17B10 (0.64) | TDP1KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL20522818 | 0.82 | HSD17B10 (0.64) | TDP1KDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL11396129 | 0.82 | HSD17B10 (0.64) | TDP1KDM4EHSD17B10ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11759435-B2 | Dihydrochalcone derivatives influencing inflammatory states | SYMRISE AG (DE) | 2023-09-19 | — | — | US | disclosed |
| US-20220226261-A1 | DIHYDROCHALCONE DERIVATIVES INFLUENCING INFLAMMATORY STATES | SYMRISE AG (DE) | 2022-07-21 | — | — | US | disclosed |
| CN-109310649-B | Dihydrochalcone derivatives affecting inflammatory states | 西姆莱斯有限公司 | 2021-06-29 | — | — | CN | disclosed |
| US-10758468-B2 | Solubilizer for cosmetic preparations | SYMRISE AG (DE) | 2020-09-01 | — | — | US | disclosed |
| EP-2633886-B1 | COMPOUNDS AND MIXTURES INFLUENCING INFLAMMATORY STATES | SYMRISE AG (DE) | 2018-01-31 | — | — | EP | disclosed |
| WO-2017186298-A1 | DIHYDROCHALCONE DERIVATIVES INFLUENCING INFLAMMATORY STATES | SYMRISE AG (DE) | 2017-11-02 | — | — | WO | disclosed |
| US-20160106650-A1 | SOLUBILIZER FOR COSMETIC PREPARATIONS | SYMRISE AG (DE) | 2016-04-21 | — | — | US | disclosed |
| US-8961943-B2 | O/W-emulsifiers, O/W-emulsions and methods of manufacture thereof | SYMRISE AG (DE) | 2015-02-24 | — | — | US | disclosed |
| US-8906958-B2 | Compounds and mixtures for influencing inflammatory states | SYMRISE AG (DE) | 2014-12-09 | — | — | US | disclosed |
| US-20130251730-A1 | Compounds and Mixtures Influencing Inflammatory States | SYMRISE AG (DE) | 2013-09-26 | — | — | US | disclosed |
| US-20130177510-A1 | O/W-EMULSIFIERS, O/W-EMULSIONS AND METHODS OF MANUFACTURE THEREOF | SYMRISE AG (DE) | 2013-07-11 | — | — | US | disclosed |
| US-8454941-B2 | O/W-emulsifiers, O/W-emulsions and methods of manufacture thereof | SYMRISE AG (DE) | 2013-06-04 | — | — | US | disclosed |
| US-20120129937-A1 | SOLUBILIZER FOR COSMETIC PREPARATIONS | SYMRISE AG (DE) | 2012-05-24 | — | — | US | disclosed |
| US-20100284948-A1 | O/W-EMULSIFIERS, O/W-EMULSIONS AND METHODS OF MANUFACTURE THEREOF | SYMRISE AG (DE) | 2010-11-11 | — | — | US | disclosed |
| US-7731982-B2 | O/W emulsifier, O/W emulsion and applications thereof | SYMRISE GMBH & CO. KG (US) | 2010-06-08 | — | — | US | disclosed |
| US-20060165738-A1 | O/w emulsifier, o/w emulsion and applications thereof | SYMRISE AG (DE) | 2006-07-27 | — | — | US | disclosed |
| US-20030171617-A1 | 3,4-Dihydroxymandelic acid alkylamides and use thereof | HAARMANN & REIMER GMBH (DE) | 2003-09-11 | — | — | US | disclosed |
| US-20030139470-A1 | 3,4-dihydroxybenzyl-substituted carbonic acid derivatives and the use thereof as antioxidants | HAARMANN & REIMER GMBH (DE) | 2003-07-24 | — | — | US | disclosed |
| US-20030072725-A1 | Topical cosmetic agents containing 2-hydrazino-1,3 -heteroazoles | HAARMANN & REIMER GMBH (DE) | 2003-04-17 | — | — | US | disclosed |
| US-20030049287-A1 | Catechol oximes and their use in cosmetic and dermatological preparations | HAARMANN & REIMER GMBH (DE) | 2003-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130251730-A1 | Compounds and Mixtures Influencing Inflammatory States | MSR1, MPO, IL1B | TDP1 3550/4885KDM4E 2721/4885HSD17B10 1122/4885 |
| US-10758468-B2 | Solubilizer for cosmetic preparations | SRPK3, SRPK1, SYMPK | TDP1 2561/4885KDM4E 1107/4885HSD17B10 650/4885 |
| US-20030171617-A1 | 3,4-Dihydroxymandelic acid alkylamides and use thereof | HNMT, HTR2A, HTR2C | TDP1 1702/4885KDM4E 1863/4885HSD17B10 663/4885 |
| US-20030049287-A1 | Catechol oximes and their use in cosmetic and dermatological preparations | TYR, LPO, COMT | TDP1 989/4885KDM4E 543/4885HSD17B10 447/4885 |
| US-20120129937-A1 | SOLUBILIZER FOR COSMETIC PREPARATIONS | SRPK3, SRPK1, SYMPK | TDP1 2561/4885KDM4E 1107/4885HSD17B10 650/4885 |
| US-20030139470-A1 | 3,4-dihydroxybenzyl-substituted carbonic acid derivatives and the use thereof as antioxidants | TYR, HAAO, TH | TDP1 745/4885KDM4E 186/4885HSD17B10 284/4885 |
| US-11759435-B2 | Dihydrochalcone derivatives influencing inflammatory states | IL17A, TNF, IL1B | TDP1 3846/4885KDM4E 2237/4885HSD17B10 37/4885 |
| US-20030072725-A1 | Topical cosmetic agents containing 2-hydrazino-1,3 -heteroazoles | TYR, MITF, HDAC1 | TDP1 508/4885KDM4E 2169/4885HSD17B10 302/4885 |
| US-20160106650-A1 | SOLUBILIZER FOR COSMETIC PREPARATIONS | SRPK3, SRPK1, SYMPK | TDP1 2561/4885KDM4E 1107/4885HSD17B10 650/4885 |
| US-20220226261-A1 | DIHYDROCHALCONE DERIVATIVES INFLUENCING INFLAMMATORY STATES | IL17A, TNF, IL1B | TDP1 3846/4885KDM4E 2237/4885HSD17B10 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.