Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | GABRP | O00591 | 4/20 | 0.34 |
| ▸ | GABRD | O14764 | 4/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.34 |
| ▸ | GABRE | P78334 | 4/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 4/20 | 0.34 |
| ▸ | GABRG3 | Q99928 | 4/20 | 0.34 |
| ▸ | GABRQ | Q9UN88 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL9895869 | 0.89 | ALDH1A1 (0.36) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL13140958 | 0.84 | ALDH1A1 (0.40) | ALDH1A1HSD17B10CYP1A2CYP2C19CYP3A4 | |
| Hydrochloric Acid SCHEMBL2938984 | 0.82 | ALDH1A1 (0.39) | ALDH1A1HSD17B10CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL2933128 | 0.81 | ALDH1A1 (0.41) | ALDH1A1HSD17B10CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL11398940 | 0.81 | NPC1 (0.42) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL14420953 | 0.80 | POLB (0.46) | ALDH1A1HSD17B10RXFP1KMT2ACYP3A4 | |
| SCHEMBL24027230 | 0.79 | ALDH1A1 (0.43) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30155004 | 0.79 | ALDH1A1 (0.43) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11397006 | 0.78 | THRB (0.37) | ALDH1A1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11386635 | 0.77 | ALDH1A1 (0.42) | ALDH1A1CYP1A2CYP2C19CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130102617-A1 | METHOD OF TREATING DIABETES, METABOLIC SYNDROME AND OBESITY USING PHENYLACETAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2013-04-25 | — | — | US | disclosed |
| US-20130102617-A1 | METHOD OF TREATING DIABETES, METABOLIC SYNDROME AND OBESITY USING PHENYLACETAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2013-04-25 | — | — | US | disclosed |
| US-20130102617-A1 | METHOD OF TREATING DIABETES, METABOLIC SYNDROME AND OBESITY USING PHENYLACETAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2013-04-25 | — | — | US | disclosed |
| US-8329707-B2 | Substituted pyrazine compounds | ASTELLAS PHARMA INC. (JP) | 2012-12-11 | — | — | US | disclosed |
| US-8329707-B2 | Substituted pyrazine compounds | ASTELLAS PHARMA INC. (JP) | 2012-12-11 | — | — | US | disclosed |
| US-8329707-B2 | Substituted pyrazine compounds | ASTELLAS PHARMA INC. (JP) | 2012-12-11 | — | — | US | disclosed |
| US-20120149718-A1 | Amido Compounds | BROTHERTON-PLEISS CHRISTINE E (US) | 2012-06-14 | — | — | US | disclosed |
| US-20100286171-A1 | PHENYLACETAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2010-11-11 | — | — | US | disclosed |
| US-20100286171-A1 | PHENYLACETAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2010-11-11 | — | — | US | disclosed |
| EP-2236498-A1 | PHENYL ACETAMIDE DERIVATIVE | Astellas Pharma Inc. (JP) | 2010-10-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286171-A1 | PHENYLACETAMIDE DERIVATIVE | AADAC, PGC, PC | ALDH1A1 2061/4885GABRP 1225/4885GABRD 1819/4885 |
| US-20130102617-A1 | METHOD OF TREATING DIABETES, METABOLIC SYNDROME AND OBESITY USING PHENYLACETAMIDE DERIVATIVE | PC, PCK2, GCKR | ALDH1A1 1865/4885GABRP 2103/4885GABRD 2908/4885 |
| US-20120149718-A1 | Amido Compounds | P2RX7, P2RX3, P2RX2 | ALDH1A1 2230/4885GABRP 184/4885GABRD 708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.