SCHEMBL3523738

SCHEMBL3523738

O=S(=O)(Cl)c1c(F)ccc(F)c1F

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.39
CA2 P00918 3/20 0.39
CA12 O43570 1/20 0.39
CA7 P43166 1/20 0.39
CA13 Q8N1Q1 1/20 0.39
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
PKM P14618 2/20 0.34
PKLR P30613 1/20 0.34
ALDH1A1 P00352 1/20 0.33
HSD17B10 Q99714 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
PTGS2 P35354 4/20 0.30
PTGS1 P23219 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30986771 1.00 CA1 (0.39) CA1CA2CA12CA7CA13
SCHEMBL31454807 0.84 PKM (0.35) CA1CA2CA12CA7CA13
SCHEMBL22146034 0.82 PTGS2 (0.34) CA1CA2CA12CA7CA13
SCHEMBL7334530 0.78 PKM (0.39) CA1CA2CA7CES2CES1
SCHEMBL22145990 0.78 TRPV4 (0.43) PKMALDH1A1PTGS2PTGS1
SCHEMBL3528750 0.78 CES2 (0.39) CES2CES1ALDH1A1HSD17B10
SCHEMBL532887 0.77 PKM (0.50) CES2CES1PKMPKLRALDH1A1
SCHEMBL4502132 0.77 CA1 (0.58) CA1CA2CA12CA7CA13
SCHEMBL29141548 0.77 CA1 (0.41) CA1CA2CA12CA7CA13
SCHEMBL8412750 0.76 PKM (0.32) PKMPKLRALDH1A1HSD17B10TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250115687-A1 PRODUCTION METHOD FOR SOLID CATALYST COMPONENT FOR POLYMERIZING OLEFINS, AND CATALYST FOR POLYMERIZAING OLEFINS FORMOSA PLASTICS CORP USA (US) 2025-04-10 US disclosed
WO-2025075722-A1 PRODUCTION METHOD FOR SOLID CATALYST COMPONENT FOR POLYMERIZING OLEFINS, AND CATALYST FOR POLYMERIZAING OLEFINS FORMOSA PLASTICS CORPORATION, U.S.A. (US) 2025-04-10 WO disclosed
CN-118344270-A Fluorine-containing diphenyl sulfone acaricide and preparation method thereof 柳州市惠农化工有限公司 2024-07-16 CN disclosed
EP-3939979-A1 JAK KINASE INHIBITOR, PREPARATION METHOD FOR SAME, AND APPLICATIONS THEREOF IN FIELD OF MEDICINE Shanghai Synergy Pharmaceutical Sciences Co., Ltd (CN) 2022-01-19 EP disclosed
CN-108698982-B Fluorine atom-containing compound and use thereof 日产化学工业株式会社 2021-07-16 CN disclosed
EP-3404017-B1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF NISSAN CHEMICAL IND LTD (JP) 2020-05-13 EP disclosed
US-10336686-B2 Fluorine atom-containing compound and use thereof NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2019-07-02 US disclosed
US-20190031600-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2019-01-31 US disclosed
EP-3404017-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF Nissan Chemical Industries, Ltd. (JP) 2018-11-21 EP disclosed
EP-2675526-B1 NOVEL SULFONAMINOQUINOLINE HEPCIDIN ANTAGONISTS VIFOR (INTERNATIONAL) AG (CH) 2017-02-01 EP disclosed
EP-1789041-A2 ARYL-PYRIDINE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS F. Hoffmann-Roche AG (CH) 2007-05-30 EP disclosed
US-20060025455-A1 New 5-aryl pyridines as 11-beta inhibitors for the treatment of diabetes HOFFMANN-LA ROCHE INC. 2006-02-02 US disclosed
WO-2006010546-A2 ARYL-PYRIDINE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS F. HOFFMAN-LA ROCHE AG (CH) 2006-02-02 WO disclosed
US-20060004062-A1 Compounds for inhibiting insulin secretion and methods related thereto MITOKOR (US) 2006-01-05 US disclosed
US-6958352-B2 Compounds for inhibiting insulin secretion and methods related thereto SMITHKLINE BEECHAM CORPORATION (US) 2005-10-25 US disclosed
EP-1472214-A2 COMPOUNDS FOR INHIBITING INSULIN SECRETION AND METHODS RELATED THERETO SmithKline Beecham Corporation (US) 2004-11-03 EP disclosed
US-20040044049-A1 Compounds for inhibiting insulin secretion and methods related thereto MITOKOR 2004-03-04 US disclosed
WO-2003066035-A2 COMPOUNDS FOR INHIBITING INSULIN SECRETION AND METHODS RELATED THERETO SMITHKLINE BEECHAM CORPORATION (US) 2003-08-14 WO disclosed
US-5811439-A ANTIDIABETIC AGENTS; SIDE EFFECT REDUCTION; ANTILEPEMIC AGENTS SENGA PHARMACEUTICAL LABORATORY INC. (JP) 1998-09-22 US disclosed
EP-0780389-A1 Thiazolidinedione derivatives, process for their preparation and pharmaceutical compositions containing them TOBISHI PHARMACEUTICAL CO., LTD. (JP) 1997-06-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10336686-B2 Fluorine atom-containing compound and use thereof ARF1, ARF5, ARFGAP1 CA1 1335/4885CA2 2792/4885CA12 2173/4885
US-20190031600-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF ARF1, ARF5, ARFGAP1 CA1 1335/4885CA2 2792/4885CA12 2173/4885
US-20060004062-A1 Compounds for inhibiting insulin secretion and methods related thereto IAPP, GPR119, INSR CA1 527/4885CA2 892/4885CA12 2293/4885
US-20040044049-A1 Compounds for inhibiting insulin secretion and methods related thereto IAPP, GPR119, IRS1 CA1 728/4885CA2 1053/4885CA12 3046/4885
US-20060025455-A1 New 5-aryl pyridines as 11-beta inhibitors for the treatment of diabetes GPR119, CYP4B1, SLC5A1 CA1 4380/4885CA2 2590/4885CA12 4429/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.