Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.65 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.65 |
| ▸ | FDPS | P14324 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 7/20 | 0.51 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.51 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.51 |
| ▸ | ABAT | P80404 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19389647 | 0.95 | ALDH1A1 (0.59) | ALDH1A1AOX1FDPSHPGDTRIM24 | |
| SCHEMBL14147477 | 0.95 | ALDH1A1 (0.59) | ALDH1A1AOX1FDPSHPGDTRIM24 | |
| SCHEMBL15952644 | 0.92 | ALDH1A1 (0.63) | ALDH1A1AOX1FDPSHPGDTRIM24 | |
| SCHEMBL1515911 | 0.87 | ALDH1A1 (0.69) | ALDH1A1AOX1FDPSHPGDTRIM24 | |
| SCHEMBL9454852 | 0.85 | ALDH1A1 (0.67) | ALDH1A1AOX1FDPSHPGDTRIM24 | |
| SCHEMBL1425341 | 0.85 | ALDH1A1 (0.62) | ALDH1A1AOX1FDPSHPGDTRIM24 | |
| SCHEMBL482374 | 0.85 | FDPS (0.77) | ALDH1A1FDPSHPGDTDP1MAPT | |
| SCHEMBL16472557 | 0.85 | ALDH1A1 (0.61) | ALDH1A1AOX1FDPSHPGDTRIM24 | |
| SCHEMBL15853568 | 0.85 | ALDH1A1 (0.61) | ALDH1A1AOX1FDPSHPGDTRIM24 | |
| SCHEMBL15952047 | 0.84 | ALDH1A1 (0.57) | ALDH1A1AOX1FDPSHPGDTRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230248837-A1 | Technology for Modulating Targeting Chimeras Induced by Cell-Penetrating Peptide and Application Thereof | LIU, MIAO (CN) | 2023-08-10 | — | — | US | disclosed |
| EP-3184520-B1 | SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF | EISAI R&D MAN CO LTD (JP) | 2022-03-23 | — | — | EP | disclosed |
| CN-106660997-B | Salts of monocyclic pyridine derivatives and crystals thereof | 卫材R&D管理有限公司 | 2019-05-21 | — | — | CN | disclosed |
| US-9951047-B2 | Salt of monocyclic pyridine derivative and crystal thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-04-24 | — | — | US | disclosed |
| US-9951047-B2 | Salt of monocyclic pyridine derivative and crystal thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-04-24 | — | — | US | disclosed |
| US-9951047-B2 | Salt of monocyclic pyridine derivative and crystal thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-04-24 | — | — | US | disclosed |
| US-20170217935-A1 | SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-08-03 | — | — | US | disclosed |
| US-20170217935-A1 | SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-08-03 | — | — | US | disclosed |
| US-20170217935-A1 | SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2017-08-03 | — | — | US | disclosed |
| EP-3184520-A1 | SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF | Eisai R&D Management Co., Ltd. (JP) | 2017-06-28 | — | — | EP | disclosed |
| US-7713994-B2 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo,1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihyro-3 (2H)-isoquinolones and methods of use thereof | WYETH LLC (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713994-B2 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo,1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihyro-3 (2H)-isoquinolones and methods of use thereof | WYETH LLC (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713994-B2 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo,1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihyro-3 (2H)-isoquinolones and methods of use thereof | WYETH LLC (US) | 2010-05-11 | — | — | US | disclosed |
| CN-101356159-A | Substituted isoquinoline-1, 3(2H,4H) -diones, 1-thio-1, 4-dihydro-2H-isoquinoline-3-ones and 1, 4-dihydro-3 (2H) -isoquinolones and their use as kinase inhibitors | WYETH CORP (US) | 2009-01-28 | — | — | CN | disclosed |
| EP-1963273-A2 | SUBSTITUTED ISOQUINOLINE-1,3(2H,4H)-DIONES, 1-THIOXO-1,4-DIHYDRO-2H-ISOQUINOLINE-3-ONES AND 1,4-DIHYDRO-3(2H)-ISOQUINOLONES AND USE THEREOF AS KINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2008-09-03 | — | — | EP | disclosed |
| US-20080085890-A1 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof | WYETH (US) | 2008-04-10 | — | — | US | disclosed |
| US-20080085890-A1 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof | WYETH (US) | 2008-04-10 | — | — | US | disclosed |
| US-20080085890-A1 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof | WYETH (US) | 2008-04-10 | — | — | US | disclosed |
| WO-2007075783-A2 | SUBSTITUTED ISOQUINOLINE-1,3(2H,4H)-DIONES, 1-THIOXO-1,4-DIHYDRO-2H-ISOQUINOLINE-3-ONES AND 1,4-DIHYDRO-3(2H)-ISOQUINOLONES AND USE THEREOF AS KINASE INHIBITOR | WYETH (US) | 2007-07-05 | — | — | WO | disclosed |
| WO-2007075783-A2 | SUBSTITUTED ISOQUINOLINE-1,3(2H,4H)-DIONES, 1-THIOXO-1,4-DIHYDRO-2H-ISOQUINOLINE-3-ONES AND 1,4-DIHYDRO-3(2H)-ISOQUINOLONES AND USE THEREOF AS KINASE INHIBITOR | WYETH (US) | 2007-07-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217935-A1 | SALT OF MONOCYCLIC PYRIDINE DERIVATIVE AND CRYSTAL THEREOF | MPST, SLC25A1, SLC16A1 | ALDH1A1 461/4885AOX1 2405/4885FDPS 419/4885 |
| US-20080085890-A1 | Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3 (2H)-isoquinolones and methods of use thereof | SULT1E1, RECQL, HAX1 | ALDH1A1 61/4885AOX1 213/4885FDPS 1238/4885 |
| US-20230248837-A1 | Technology for Modulating Targeting Chimeras Induced by Cell-Penetrating Peptide and Application Thereof | VIP, GHITM, MYCBP | ALDH1A1 4851/4885AOX1 4755/4885FDPS 1690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.