Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 1/20 | 0.72 |
| ▸ | GABRD | O14764 | 1/20 | 0.72 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.72 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.72 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.72 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.72 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.72 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.72 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.72 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.72 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.72 |
| ▸ | GABRE | P78334 | 1/20 | 0.72 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.72 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.72 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.72 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10862685 | 0.91 | ADORA3 (0.67) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10712253 | 0.88 | ADORA3 (0.63) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL3567661 | 0.88 | ADORA3 (0.62) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10715388 | 0.88 | ADORA3 (0.62) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10713041 | 0.87 | ADORA3 (0.62) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL22987949 | 0.85 | KDM4E (0.72) | ADORA3KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10712450 | 0.85 | GABRP (0.80) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL29646331 | 0.85 | GABRP (0.80) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10712254 | 0.84 | GABRP (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL29646479 | 0.84 | GABRP (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293730-B2 | Substituted imidazo[1,5-A][1,2,4]triazolo[1,5-D][1,4]benzodiazepine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-20100075954-A1 | SUBSTITUTED IMIDAZO[1,5-A][1,2,4]TRIAZOLO[1,5-D][1,4]BENZODIAZEPINE DERIVATIVES | KNUST HENNER | 2010-03-25 | — | — | US | disclosed |
| US-7671048-B2 | Substituted imidazo [1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-03-02 | — | — | US | disclosed |
| US-7507728-B2 | Halogen substituted imidazol[1,5-A][1,2,4]triazolo[1,5-D][1,4]benzodiazepine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-03-24 | — | — | US | disclosed |
| EP-1809297-B1 | IMIDAZO[1,5A]TRIAZOLO[1,5D]BENZODIAZEPINE DERIVATIVES FOR THE TREATMENT OF COGNITIVE DISORDERS | HOFFMANN LA ROCHE (CH) | 2008-07-30 | — | — | EP | disclosed |
| EP-1807432-A1 | HALOGEN SUBSTITUTED BENZODIAZEPINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006045429-A1 | HALOGEN SUBSTITUTED BENZODIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-04 | — | — | WO | disclosed |
| US-20060084801-A1 | Halogen substituted imidazol[1,5-A][1,2,4]triazolo[1,5-D][1,4]benzodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2006-04-20 | — | — | US | disclosed |
| US-20060079507-A1 | Substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives | HOFFMANN-LA ROCHE INC. | 2006-04-13 | — | — | US | disclosed |
| US-4713383-A | ADENOSINE AND BENZODIAZEPINE ANTAGONISTS | CIBA-GEIGY CORPORATION (US) | 1987-12-15 | — | — | US | disclosed |
| EP-0181282-A1 | Triazoloquinazoline compounds | CIBA-GEIGY AG (CH) | 1986-05-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060079507-A1 | Substituted imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine derivatives | GABRA3, GABRA1, OXER1 | GABRP 61/4885GABRD 64/4885GABRA1 2/4885 |
| US-20060084801-A1 | Halogen substituted imidazol[1,5-A][1,2,4]triazolo[1,5-D][1,4]benzodiazepine derivatives | GABRA1, GABRA4, GABRA5 | GABRP 31/4885GABRD 21/4885GABRA1 1/4885 |
| US-20100075954-A1 | SUBSTITUTED IMIDAZO[1,5-A][1,2,4]TRIAZOLO[1,5-D][1,4]BENZODIAZEPINE DERIVATIVES | GABRA1, GABRA5, ADRA1A | GABRP 16/4885GABRD 61/4885GABRA1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.