SCHEMBL357343

SCHEMBL357343

O=[N+]([O-])c1ccc(O[PH](=O)Oc2ccc([N+](=O)[O-])cc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSPB1 P04792 1/20 0.52
CA1 P00915 3/20 0.50
CA2 P00918 3/20 0.50
CES1 P23141 2/20 0.50
CA9 Q16790 1/20 0.50
CES2 O00748 1/20 0.50
ALDH1A1 P00352 3/20 0.46
HSD17B10 Q99714 2/20 0.46
ACHE P22303 2/20 0.46
LMNA P02545 2/20 0.46
MAPK1 P28482 2/20 0.46
GAA P10253 1/20 0.46
TP53 P04637 1/20 0.46
CYP3A4 P08684 1/20 0.46
THRB P10828 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
MAPT P10636 2/20 0.44
MEN1 O00255 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5409494 0.92 ALDH1A1 (0.54) HSPB1CA1CA2CES1CA9
SCHEMBL23844032 0.86 ALDH1A1 (0.43) HSPB1CA1CA2CES1CA9
SCHEMBL10745979 0.84 CA1 (0.50) HSPB1CA1CA2CES1CA9
SCHEMBL30777840 0.83 HSPB1 (0.48) HSPB1CA1CA2CES1CA9
SCHEMBL15588700 0.83 HSPB1 (0.48) HSPB1CA1CA2CES1CA9
SCHEMBL357344 0.83 CA1 (0.52) HSPB1CA1CA2CES1CA9
SCHEMBL5712600 0.82 HPGD (0.45) HSPB1ALDH1A1HSD17B10LMNAMAPK1
SCHEMBL18476534 0.80 ALOX5 (0.47) HSPB1ALDH1A1LMNAGAACYP3A4
SCHEMBL7148173 0.80 PTGS2 (0.40) HSPB1CA1CA2CES1CA9
SCHEMBL28803957 0.80 CA1 (0.41) HSPB1CA1CA2CES1CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 155 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250326723-A1 Development of an Enzyme-Inhibitor Reaction Using Cellular Retinoic Acid Binding Protein II for One-Pot Megamolecule Assembly UNIV NORTHWESTERN (US) 2025-10-23 US claimed
WO-2024025604-A9 DEVELOPMENT OF AN ENZYME-INHIBITOR REACTION USING CELLULAR RETINOIC ACID BINDING PROTEIN II FOR ONE-POT MEGAMOLECULE ASSEMBLY NORTHWESTERN UNIVERSITY (US) 2024-05-02 WO claimed
WO-2024025604-A2 DEVELOPMENT OF AN ENZYME-INHIBITOR REACTION USING CELLULAR RETINOIC ACID BINDING PROTEIN II FOR ONE-POT MEGAMOLECULE ASSEMBLY NORTHWESTERN UNIVERSITY (US) 2024-02-01 WO claimed
US-20190161556-A1 Fusion Protein Construct NORTHWESTERN UNIVERSITY 2019-05-30 US claimed
EP-3464384-A1 FUSION PROTEIN CONSTRUCT Northwestern University (US) 2019-04-10 EP claimed
WO-2017214151-A1 FUSION PROTEIN CONSTRUCT NORTHWESTERN UNIVERSITY (US) 2017-12-14 WO claimed
EP-2311939-A1 Polypeptide immobilization The University of Chicago (US) 2011-04-20 EP claimed
US-7888055-B2 Selectively binds with absolute control over orientation and density without requiring prior synthetic modification or purification to make a stable protein chip; rapid and irreversible; assaying kinase or protease activity THE UNIVERSITY OF CHICAGO (US) 2011-02-15 US claimed
EP-1196631-A1 POLYNUCLEOTIDES Cyclops Genome Sciences Limited (GB) 2002-04-17 EP claimed
WO-2001094626-A1 POLYNUCLEOTIDES CYCLOPS GENOME SCIENCES LIMITED (GB) 2001-12-13 WO claimed
WO-2000066605-A2 POLYNUCLEOTIDES CYCLOPS GENOME SCIENCES LIMITED (GB) 2000-11-09 WO claimed
US-5272035-A Photosensitive lithographic printing plate having treated aluminum support with diazonium light-sensitive layer containing polyurethane resin and phosphorous additive FUJI PHOTO FILM CO., LTD. (JP) 1993-12-21 US claimed
WO-2026101423-A1 PHOTOSWITCHABLE CHEMICAL INDUCED DIMERIZATION SYSTEMS FOR CONTROL OF CELLULAR ACTIVITIES WITH LIGHT WU YAOWEN (SE) 2026-05-15 WO disclosed
US-20260063641-A1 COMPOSITIONS AND METHODS FOR LABELING AND DETECTING BINDING PARTNERS UNIV UTAH RES FOUND (US) 2026-03-05 US disclosed
US-20250326723-A1 Development of an Enzyme-Inhibitor Reaction Using Cellular Retinoic Acid Binding Protein II for One-Pot Megamolecule Assembly UNIV NORTHWESTERN (US) 2025-10-23 US disclosed
EP-4565594-A2 COMPOSITIONS AND METHODS FOR LABELING AND DETECTING BINDING PARTNERS University of Utah Research Foundation (US) 2025-06-11 EP disclosed
CN-86108176-A Lankacidin derivatives and process for producing the same 1987-10-21 CN disclosed
US-4308197-A POLYIMIDE OR POLYEPOXIDE AND AN AMMONIUM OR AMINE SALT OF AN ORGANIC PHOSPHONIC OR PHOSPHINIC ACID; CHAR STABILITY; AIRCRAFT MCDONNELL DOUGLAS CORPORATION (US) 1981-12-29 US disclosed
US-4303766-A SULFONATION OF ELASTOMERS, FRIEDEL-CRAFTS OR COORDINATION CATALYST, ACYL SULFATE, QUENCHING, NEUTRALIZATION EXXON RESEARCH & ENGINEERING CO. (US) 1981-12-01 US disclosed
US-4105647-A SOLUTION POLYMERIZATION USING A FRIEDEL-CRAFTS OF ZIEGLER-TYPE CATALYST EXXON RESEARCH & ENGINEERING CO. (US) 1978-08-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260063641-A1 COMPOSITIONS AND METHODS FOR LABELING AND DETECTING BINDING PARTNERS ATIC, JMJD7, UCHL1 HSPB1 2357/4885CA1 4569/4885CA2 4467/4885
US-20190161556-A1 Fusion Protein Construct RPS27A, CD2BP2, JMJD7 HSPB1 771/4885CA1 1971/4885CA2 2987/4885
US-20250326723-A1 Development of an Enzyme-Inhibitor Reaction Using Cellular Retinoic Acid Binding Protein II for One-Pot Megamolecule Assembly CRABP2, RARB, RARA HSPB1 2256/4885CA1 1293/4885CA2 620/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.