Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 4/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3570220 | 0.91 | KDM5A (0.40) | LPAR1LPAR5PTGER2KMT2AHCRTR1 | |
| SCHEMBL3569982 | 0.90 | LPAR1 (0.41) | MEP1BMAPTTSHRLPAR1LPAR5 | |
| SCHEMBL3579507 | 0.85 | HDAC8 (0.41) | KMT2APPARGPPARANR1H4SLC2A1 | |
| SCHEMBL3575452 | 0.81 | KMT2A (0.42) | KMT2APPARGPPARANR1H4MEN1 | |
| SCHEMBL3570707 | 0.81 | C5AR1 (0.39) | MAPTLPAR1LPAR5KMT2APPARG | |
| SCHEMBL3578799 | 0.81 | TP53 (0.39) | MAPTLPAR1LPAR5KMT2APPARG | |
| SCHEMBL3575602 | 0.80 | LPAR1 (0.38) | MAPTLPAR1LPAR5KMT2AHCRTR1 | |
| SCHEMBL3587595 | 0.80 | C5AR1 (0.49) | LPAR1LPAR5KMT2ANR1H4PTGES | |
| SCHEMBL3581034 | 0.77 | LPAR1 (0.36) | MEP1BMAPTLPAR1LPAR5PPARG | |
| SCHEMBL3574076 | 0.77 | HDAC1 (0.52) | LPAR1LPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |