Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3586118 | 0.89 | ALDH1A1 (0.46) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3576836 | 0.86 | CYP1A2 (0.53) | ALDH1A1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL3584966 | 0.83 | SMN1; SMN2 (0.39) | MAPTMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL3586569 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL5036089 | 0.76 | ALOX15 (0.55) | ALDH1A1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL3578518 | 0.75 | TUBB4A (0.61) | ALDH1A1MAPTKMT2AKDM4EMAPK1 | |
| SCHEMBL3589987 | 0.69 | CRHBP (0.41) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL2876735 | 0.69 | LMNA (0.56) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL11652356 | 0.69 | CYP1A2 (0.80) | ALDH1A1MAPTKMT2AMAPK1CYP1A2 | |
| SCHEMBL3579446 | 0.69 | CRHBP (0.53) | ALDH1A1MAPTMAPK1TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113421-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113421-A1 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | RTF1, RNGTT, POLR2E | ALDH1A1 2016/4885MAPT 1265/4885MEN1 4584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.