Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.50 |
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15135221 | 0.83 | MEN1 (0.50) | KMT2AMEN1KDM4EPKML3MBTL1 | |
| SCHEMBL732131 | 0.83 | KDM4E (0.74) | KMT2AMEN1KDM4EPKML3MBTL1 | |
| SCHEMBL29382173 | 0.83 | KDM4E (0.74) | KMT2AMEN1KDM4EPKML3MBTL1 | |
| SCHEMBL28118425 | 0.82 | ALDH1A1 (0.77) | KMT2AMEN1KDM4EL3MBTL1LMNA | |
| SCHEMBL28110243 | 0.82 | KDM4E (0.56) | KMT2AMEN1KDM4EPKML3MBTL1 | |
| SCHEMBL11267266 | 0.82 | KDM4E (0.56) | KMT2AMEN1KDM4EPKML3MBTL1 | |
| SCHEMBL3432751 | 0.81 | ACHE (0.59) | KMT2AMEN1KDM4EPKML3MBTL1 | |
| SCHEMBL13950894 | 0.80 | KDM4E (0.78) | KMT2AMEN1KDM4EPKML3MBTL1 | |
| SCHEMBL865711 | 0.80 | KDM4E (0.71) | KMT2AMEN1KDM4EPKML3MBTL1 | |
| SCHEMBL28710728 | 0.80 | KDM4E (0.71) | KMT2AMEN1KDM4EPKML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106220575-B | A kind of hydrazone compounds and the preparation method and application thereof of the structure of benzopyrazines containing methoxyl group | 浙江工业大学 | 2019-02-22 | — | — | CN | claimed |
| CN-106243049-B | A kind of hydrazone compounds of the structure containing benzopyrazines and the preparation method and application thereof | 浙江工业大学 | 2019-01-15 | — | — | CN | claimed |
| CN-106243049-A | A kind of hydrazone compounds containing benzopyrazines structure and preparation method and application | 浙江工业大学 | 2016-12-21 | — | — | CN | claimed |
| CN-106220575-A | A kind of hydrazone compounds containing methoxyl group benzopyrazines structure and preparation method and application | 浙江工业大学 | 2016-12-14 | — | — | CN | claimed |
| CN-106234372-B | A kind of application of hydrazone compounds of the structure of benzopyrazines containing methoxyl group as fungicide | 浙江工业大学 | 2019-06-21 | — | — | CN | disclosed |
| CN-106234371-B | A kind of application of hydrazone compounds of the structure containing benzopyrazines as fungicide | 浙江工业大学 | 2019-04-26 | — | — | CN | disclosed |
| CN-106220575-B | A kind of hydrazone compounds and the preparation method and application thereof of the structure of benzopyrazines containing methoxyl group | 浙江工业大学 | 2019-02-22 | — | — | CN | disclosed |
| CN-106243049-B | A kind of hydrazone compounds of the structure containing benzopyrazines and the preparation method and application thereof | 浙江工业大学 | 2019-01-15 | — | — | CN | disclosed |
| US-9763938-B2 | Substituted quinoxalines as positive allosteric modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2017-09-19 | — | — | US | disclosed |
| US-9763938-B2 | Substituted quinoxalines as positive allosteric modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2017-09-19 | — | — | US | disclosed |
| US-9763938-B2 | Substituted quinoxalines as positive allosteric modulators of mGluR4 | MERCK PATENT GMBH (DE) | 2017-09-19 | — | — | US | disclosed |
| CN-106234372-A | A kind of hydrazone compounds containing methoxyl group benzopyrazines structure is as the application of antibacterial | 浙江工业大学 | 2016-12-21 | — | — | CN | disclosed |
| WO-2012092409-A2 | MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARARMACEUTICALS, INC (US) | 2012-07-05 | — | — | WO | disclosed |
| US-20120172291-A1 | MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ABBVIE INC. | 2012-07-05 | — | — | US | disclosed |
| US-20120172291-A1 | MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ABBVIE INC. | 2012-07-05 | — | — | US | disclosed |
| CN-101685733-A | High-temperature thermal fuse device | THERM O DISC INC | 2010-03-31 | — | — | CN | disclosed |
| US-20100029658-A1 | HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2010-02-04 | — | — | US | disclosed |
| US-20100029658-A1 | HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2010-02-04 | — | — | US | disclosed |
| EP-2061764-A1 | HETEROCYCLIC DERIVATIVES BINDING TO THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR (PBR) | Technion Research & Development Foundation LTD. (IL) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008023357-A1 | HETEROCYCLIC DERIVATIVES BINDING TO THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR (PBR) | TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. (IL) | 2008-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172291-A1 | MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | TMPRSS15, PRSS1, SPINT2 | KMT2A 3992/4885MEN1 3179/4885KDM4E 3420/4885 |
| US-20100029658-A1 | HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | NQO1, SIRT5, KEAP1 | KMT2A 2240/4885MEN1 1210/4885KDM4E 1814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.