Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL865712 | 0.80 | TSHR (0.44) | CES2CES1SMN1; SMN2ALOX15TSHR | |
| SCHEMBL3609237 | 0.78 | NPC1 (0.38) | CES2CES1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL1196135 | 0.78 | ABL1 (0.43) | RAB9ASMN1; SMN2NPC1MAPTTSHR | |
| SCHEMBL3617819 | 0.78 | ALDH1A1 (0.40) | RAB9AHTTSMN1; SMN2NPC1KMT2A | |
| SCHEMBL3062621 | 0.76 | MAPT (0.41) | CES2CES1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8463456 | 0.76 | ALDH1A1 (0.41) | CES2CES1RAB9AHTTSMN1; SMN2 | |
| SCHEMBL1601408 | 0.74 | CES2 (0.34) | CES2CES1MEN1KMT2AMAOB | |
| SCHEMBL6204341 | 0.74 | ALDH1A1 (0.52) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL3956678 | 0.71 | HPGD (0.43) | CES2CES1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL6174528 | 0.71 | ALDH1A1 (0.41) | RAB9ANPC1KMT2ALMNAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410155-B2 | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIA inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-02 | — | — | US | claimed |
| US-20100016316-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2010-01-21 | — | — | US | claimed |
| EP-2102189-A2 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-09-23 | — | — | EP | claimed |
| WO-2008076805-A2 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-26 | — | — | WO | claimed |
| EP-3666777-B1 | DIBENZOPYRROMETHENE BORON CHELATE COMPOUND, NEAR-INFRARED LIGHT-ABSORBING MATERIAL, THIN-FILM, AND ORGANIC ELECTRONIC DEVICE | NIPPON KAYAKU KK (JP) | 2023-10-11 | — | — | EP | disclosed |
| WO-2023078252-A1 | PPARG INVERSE AGONISTS AND USES THEREOF | FLARE THERAPEUTICS INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| CN-110637023-B | Dibenzopyrrole methine boron chelate compound, near infrared light absorbing material, thin film, and organic electronic device | 日本化药株式会社 | 2022-07-08 | — | — | CN | disclosed |
| US-10749116-B1 | Dibenzopyrromethene boron chelate compound, near-infrared light-absorbing material, thin-film, and organic electronic device | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2020-08-18 | — | — | US | disclosed |
| US-20200243774-A1 | Dibenzopyrromethene Boron Chelate Compound, Near-Infrared Light-Absorbing Material, Thin-Film, and Organic Electronic Device | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2020-07-30 | — | — | US | disclosed |
| CN-110637023-A | Dibenzopyrrole methine boron chelate compound, near-infrared light absorbing material, thin film and organic electronic device | 日本化药株式会社 | 2019-12-31 | — | — | CN | disclosed |
| US-8410155-B2 | Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIA inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-02 | — | — | US | disclosed |
| US-20100016316-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2010-01-21 | — | — | US | disclosed |
| EP-2102189-A2 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008076805-A2 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200243774-A1 | Dibenzopyrromethene Boron Chelate Compound, Near-Infrared Light-Absorbing Material, Thin-Film, and Organic Electronic Device | CX3CR1, CRY1, PAX3 | CES2 3569/4885CES1 4191/4885RAB9A 1220/4885 |
| US-10749116-B1 | Dibenzopyrromethene boron chelate compound, near-infrared light-absorbing material, thin-film, and organic electronic device | CX3CR1, CRY1, PAX3 | CES2 3512/4885CES1 4178/4885RAB9A 1253/4885 |
| US-20100016316-A1 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | F12, TFPI, F11 | CES2 3073/4885CES1 1498/4885RAB9A 1667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.