Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 4/20 | 0.41 |
| ▸ | FAAH | O00519 | 4/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10931031 | 1.00 | MGLL (0.41) | MGLLFAAHALOX5KMT2ASMN1; SMN2 | |
| SCHEMBL10794655 | 1.00 | MGLL (0.41) | MGLLFAAHALOX5KMT2ASMN1; SMN2 | |
| SCHEMBL5847509 | 0.98 | FAAH (0.39) | MGLLFAAHALOX5KMT2ASMN1; SMN2 | |
| SCHEMBL20503180 | 0.92 | FAAH (0.36) | MGLLFAAHALOX5KMT2ASMN1; SMN2 | |
| SCHEMBL20503205 | 0.83 | FAAH (0.34) | MGLLFAAHPTGS1PTGS2CYP2C9 | |
| SCHEMBL12485891 | 0.83 | BRD4 (0.31) | MGLLFAAH | |
| SCHEMBL11265727 | 0.78 | FAAH (0.37) | MGLLFAAHALOX5KMT2ACYP2C9 | |
| SCHEMBL10929035 | 0.76 | MGLL (0.52) | MGLLFAAHSMN1; SMN2PTGS1PTGS2 | |
| SCHEMBL1163645 | 0.76 | MGLL (0.52) | MGLLFAAHSMN1; SMN2PTGS1PTGS2 | |
| SCHEMBL20503201 | 0.74 | ALDH1A1 (0.33) | MAPTTHRBALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522916-B2 | A1 adenosine receptor antagonists | WILSON CONSTANCE NEELY (US) | 2016-12-20 | — | — | US | disclosed |
| US-9345776-B2 | Biodegradable polymers with sulfenamide bonds for drug delivery applications | THE UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-05-24 | — | — | US | disclosed |
| US-20140099506-A1 | Biodegradable Polymers with Sulfenamide Bonds for Drug Delivery Applications | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2014-04-10 | — | — | US | disclosed |
| US-20140031375-A1 | A1 ADENOSINE RECEPTOR ANTAGONISTS | WILSON CONSTANCE NEELY (US) | 2014-01-30 | — | — | US | disclosed |
| US-20100222257-A1 | SUBSTITUTED PHENETHYLAMINES | AUSPEX PHARMACEUTICALS, INC. (US) | 2010-09-02 | — | — | US | disclosed |
| EP-2222676-A2 | A1 ADENOSINE RECEPTOR ANTAGONISTS | Endacea, Inc. (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009086077-A2 | A1 ADENOSINE RECEPTOR ANTAGONISTS | ENDACEA, INC. (US) | 2009-07-09 | — | — | WO | disclosed |
| US-20090068101-A9 | A1 Adenosine Receptor Antagonists | ENDACEA, INC. (US) | 2009-03-12 | — | — | US | disclosed |
| EP-1636229-A4 | A1 ADENOSINE RECEPTOR ANTOGONISTS | ENDACEA INC (US) | 2008-07-30 | — | — | EP | disclosed |
| US-20070282105-A1 | A1 ADENOSINE RECEPTOR ANTAGONISTS | ENDACEA, INC. (US) | 2007-12-06 | — | — | US | disclosed |
| US-20070274910-A1 | e.g. 3-[2-(2-Aminophenyl)ethyl]-8-benzyl-7-(2-methylamino)ethyl-1-propylxanthine; A1-adenosine receptor antagonist; antiallergen, antiinflammatory agent; AIDS and immune deficiency disorders, asthma; good water solubility | ENDACEA, INC. (US) | 2007-11-29 | — | — | US | disclosed |
| US-7247639-B2 | A1 adenosine receptor antagonists | ENDACEA, INC. (US) | 2007-07-24 | — | — | US | disclosed |
| EP-1636230-A2 | A1 ADENOSINE RECEPTOR ANTAGONISTS | Endacea, Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| EP-1636229-A2 | A1 ADENOSINE RECEPTOR ANTOGONISTS | Endacea, Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| US-20050187226-A1 | A1 adenosine receptor antagonists | ENDACEA, INC. | 2005-08-25 | — | — | US | disclosed |
| WO-2005009343-A2 | A1 ADENOSINE RECEPTOR ANTOGONISTS | ENDACEA, INC. (US) | 2005-02-03 | — | — | WO | disclosed |
| WO-2004110379-A2 | A1 ADENOSINE RECEPTOR ANTAGONISTS | ENDACEA, INC. (US) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140099506-A1 | Biodegradable Polymers with Sulfenamide Bonds for Drug Delivery Applications | STS, HPSE, MPST | MGLL 1565/4885FAAH 1060/4885ALOX5 2832/4885 |
| US-20070282105-A1 | A1 ADENOSINE RECEPTOR ANTAGONISTS | ADORA1, ADORA3, ADORA2A | MGLL 3223/4885FAAH 786/4885ALOX5 1767/4885 |
| US-20070274910-A1 | e.g. 3-[2-(2-Aminophenyl)ethyl]-8-benzyl-7-(2-methylamino)ethyl-1-propylxanthine; A1-adenosine receptor antagonist; antiallergen, antiinflammatory agent; AIDS and immune deficiency disorders, asthma; good water solubility | HRH3, HRH1, HRH2 | MGLL 4141/4885FAAH 42/4885ALOX5 148/4885 |
| US-20140031375-A1 | A1 ADENOSINE RECEPTOR ANTAGONISTS | ADORA1, ADORA2A, ADORA3 | MGLL 3474/4885FAAH 940/4885ALOX5 1455/4885 |
| US-20100222257-A1 | SUBSTITUTED PHENETHYLAMINES | ADRB1, ADRA2C, ADRB2 | MGLL 2239/4885FAAH 1433/4885ALOX5 2574/4885 |
| US-20050187226-A1 | A1 adenosine receptor antagonists | ADORA1, ADORA2A, ADORA3 | MGLL 3473/4885FAAH 664/4885ALOX5 1580/4885 |
| US-20090068101-A9 | A1 Adenosine Receptor Antagonists | ADORA1, ADORA3, ADORA2A | MGLL 4276/4885FAAH 51/4885ALOX5 742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.