Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.44 |
| ▸ | BAD | Q92934 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14705876 | 0.87 | ALDH1A1 (0.49) | KDM4EBCL2L1BADGPR35ALDH1A1 | |
| SCHEMBL17233734 | 0.85 | AURKB (0.42) | KDM4EBCL2L1BADALDH1A1AURKB | |
| SCHEMBL29757272 | 0.85 | IKBKB (0.43) | KMT2AAURKBMETKDRMEN1 | |
| SCHEMBL319126 | 0.84 | ALDH1A1 (0.58) | KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL21176862 | 0.83 | PRKAB2 (0.48) | KDM4EALDH1A1KMT2AUSP2HPGD | |
| SCHEMBL15334363 | 0.81 | SLC6A3 (0.59) | KDM4EALDH1A1KMT2AAURKBMET | |
| SCHEMBL18256953 | 0.81 | IKBKB (0.47) | KDM4EALDH1A1KMT2AAURKBMET | |
| SCHEMBL23158698 | 0.79 | NR4A2 (0.38) | KDM4EBCL2L1BADALDH1A1AURKB | |
| SCHEMBL699308 | 0.77 | PRKCZ (0.49) | KDM4EALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL22210777 | 0.77 | AURKB (0.42) | KDM4EALDH1A1KMT2AAURKBMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867223-B1 | NOVEL FUSED PYRIDINE DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS | BETTA PHARMACEUTICALS CO LTD (CN) | 2018-09-05 | — | — | EP | claimed |
| US-9617257-B2 | Fused pyridine derivatives useful as c-Met tyrosine kinase inhibitors | BETTA PHARMACEUTICALS CO., LTD (CN) | 2017-04-11 | — | — | US | claimed |
| EP-2593462-B1 | NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS C-MET TYROSINE KINASE INHIBITORS | BETTA PHARMACEUTICALS CO LTD (CN) | 2016-09-07 | — | — | EP | claimed |
| US-9242991-B2 | Substituted fused heterocycles as c-Met tyrosine kinase inhibitors | BETTA PHARMACEUTICALS CO., LTD (CN) | 2016-01-26 | — | — | US | claimed |
| US-20150315210-A1 | NOVEL FUSED PYRIDINE DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS | BETTA PHARMACEUTICALS CO., LTD. (CN) | 2015-11-05 | — | — | US | claimed |
| US-20130123286-A1 | Novel Fused Heterocyclic Derivatives Useful as c-Met Tyrosine Kinase Inhibitors | BETTA PHARMACEUTICALS CO., LTD. (CN) | 2013-05-16 | — | — | US | claimed |
| US-12371428-B2 | Pyridone compounds and methods of use | EXELIXIS, INC. (US) | 2025-07-29 | — | — | US | disclosed |
| WO-2024251182-A1 | QUINOXALINE COMPOUND AND USE THEREOF | 广州六顺生物科技有限公司 | 2024-12-12 | — | — | WO | disclosed |
| CN-119101036-A | Quinoxaline compound and application thereof | 广州六顺生物科技有限公司 | 2024-12-10 | — | — | CN | disclosed |
| CN-114907339-B | 4- (4-aminophenoxy) pyridin-2-amine derivatives and use thereof | 成都奥睿药业有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-114716440-B | Pyrrolotriazine derivatives, and preparation method and application thereof | 广州六顺生物科技股份有限公司 | 2023-06-30 | — | — | CN | disclosed |
| US-20230203029-A1 | NAPHTHYRIDINE COMPOUNDS AS INHIBITORS OF MER TYROSINE KINASE AND AXL TYROSINE KINASE | EVOTEC (UK) LIMITED (GB) | 2023-06-29 | — | — | US | disclosed |
| EP-4126238-A1 | NAPHTHYRIDINE COMPOUNDS AS INHIBITORS OF MER TYROSINE KINASE AND AXL TYROSINE KINASE | Kinsensus Limited (GB) | 2023-02-08 | — | — | EP | disclosed |
| CN-101977906-A | 4-pyridinone compounds and their use for cancer | BRISTOL MYERS SQUIBB CO | 2011-02-16 | — | — | CN | disclosed |
| CN-101977905-A | 4-pyridinone compounds and their use for cancer | BRISTOL MYERS SQUIBB CO | 2011-02-16 | — | — | CN | disclosed |
| WO-2011017142-A1 | NOVEL BICYCLIC UREA COMPOUNDS | MERCK PATENT GMBH (DE) | 2011-02-10 | — | — | WO | disclosed |
| US-20110034416-A1 | 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER | BRISTOL-MYERS SQUIBB COMPANY | 2011-02-10 | — | — | US | disclosed |
| US-20110034416-A1 | 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER | BRISTOL-MYERS SQUIBB COMPANY | 2011-02-10 | — | — | US | disclosed |
| WO-2009094417-A1 | 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-07-30 | — | — | WO | disclosed |
| WO-2009094427-A1 | 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034416-A1 | 4-PYRIDINONE COMPOUNDS AND THEIR USE FOR CANCER | DPYD, CDK4, G6PD | KDM4E 1712/4885BCL2L1 2693/4885BAD 2020/4885 |
| US-20150315210-A1 | NOVEL FUSED PYRIDINE DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS | MET, ABL1, ROS1 | KDM4E 900/4885BCL2L1 2253/4885BAD 3309/4885 |
| US-12371428-B2 | Pyridone compounds and methods of use | PDXK, PLK2, MAP4K2 | KDM4E 2816/4885BCL2L1 3877/4885BAD 3025/4885 |
| US-20130123286-A1 | Novel Fused Heterocyclic Derivatives Useful as c-Met Tyrosine Kinase Inhibitors | MET, RET, ABL1 | KDM4E 1318/4885BCL2L1 2420/4885BAD 3578/4885 |
| US-20230203029-A1 | NAPHTHYRIDINE COMPOUNDS AS INHIBITORS OF MER TYROSINE KINASE AND AXL TYROSINE KINASE | MERTK, AXL, TYRO3 | KDM4E 2105/4885BCL2L1 1004/4885BAD 1732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.