Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HMGCR | P04035 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5669064 | 0.78 | SOAT2 (0.48) | MTNR1ANLRP3KAT6A | |
| SCHEMBL8720139 | 0.72 | FFAR4 (0.43) | FLT1FLT4KDRMTNR1ANLRP3 | |
| SCHEMBL6941987 | 0.72 | PTPN1 (0.41) | MTNR1ANLRP3PTPN1PTPN11GPR84 | |
| SCHEMBL1952267 | 0.70 | CA2 (0.37) | MTNR1AFFAR4PTPN1PTPN11GPR84 | |
| SCHEMBL11684526 | 0.68 | HPGD (0.37) | PTPN1PTPN11HMGCRALDH1A1 | |
| SCHEMBL9080680 | 0.67 | L3MBTL1 (0.46) | PTPN1PTPN11LMNAALDH1A1 | |
| SCHEMBL18243922 | 0.67 | PTPN1 (0.34) | MTNR1AFFAR4PTPN1PTPN11GPR84 | |
| SCHEMBL6936615 | 0.66 | PPARG (0.36) | PTPN1PTPN11GPR84PLK1LMNA | |
| SCHEMBL18242177 | 0.65 | ALOX5 (0.36) | MTNR1AFFAR4PTPN1PTPN11HMGCR | |
| SCHEMBL4960554 | 0.64 | HTT (0.53) | PTPN1PTPN11HIF1AHMGCRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158203-A2 | PYRIMIDINEDIONE DERIVATIVES AND USE THEREOF | SCHERING CORPORATION (US) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008127591-A2 | PYRIMIDINEDIONE DERIVATIVES AND USE THEREOF | SCHERING CORPORATION (US) | 2008-10-23 | — | — | WO | disclosed |
| EP-1841460-A2 | THERAPEUTIC FORMULATIONS FOR THE TREATMENT OF BETA-AMYLOID RELATED DISEASES | Neurochem (International) Limited (CH) | 2007-10-10 | — | — | EP | disclosed |
| WO-2007049098-A2 | THERAPEUTIC FORMULATIONS FOR THE TREATMENT OF BETA-AMYLOID RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-05-03 | — | — | WO | disclosed |
| EP-1585520-A1 | THERAPEUTIC FORMULATIONS FOR THE TREATMENT OF BETA-AMYLOID RELATED DISEASES | Neurochem (International) Limited (CH) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004058258-A1 | THERAPEUTIC FORMULATIONS FOR THE TREATMENT OF BETA-AMYLOID RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2004-07-15 | — | — | WO | disclosed |