Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 10/20 | 0.36 |
| ▸ | PPARA | Q07869 | 10/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940643 | 0.85 | PPARG (0.40) | PPARGPPARALMNAMAPTXBP1 | |
| SCHEMBL6941987 | 0.78 | PTPN1 (0.41) | PPARGPPARAPTPN1PTPN11LMNA | |
| SCHEMBL147801 | 0.71 | CNR1 (0.37) | PTPN1PTPN11GPR84 | |
| SCHEMBL6936875 | 0.70 | ALDH1A1 (0.34) | PPARGPPARAPTPN1PTPN11 | |
| SCHEMBL5704698 | 0.69 | — | — | |
| SCHEMBL11684526 | 0.67 | HPGD (0.37) | PTPN1PTPN11 | |
| SCHEMBL9080680 | 0.66 | L3MBTL1 (0.46) | PTPN1PTPN11LMNAL3MBTL1THRB | |
| SCHEMBL18243922 | 0.66 | PTPN1 (0.34) | PTPN1PTPN11GPR84PLK1 | |
| SCHEMBL5048782 | 0.66 | PTGS2 (0.33) | PLK1 | |
| SCHEMBL3633717 | 0.66 | FLT1 (0.34) | PTPN1PTPN11LMNAMAPTXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003513909-A | — | — | 2003-04-15 | — | — | JP | claimed |
| EP-1229907-A1 | PREVENTION OF PLAQUE RUPTURE BY ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-08-14 | — | — | EP | claimed |
| WO-2001034127-A1 | PREVENTION OF PLAQUE RUPTURE BY ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-05-17 | — | — | WO | claimed |
| EP-1229907-A1 | PREVENTION OF PLAQUE RUPTURE BY ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2002-08-14 | — | — | EP | disclosed |
| WO-2001034127-A1 | PREVENTION OF PLAQUE RUPTURE BY ACAT INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-05-17 | — | — | WO | disclosed |