Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyruvate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 known ✓ | P22748 | 4/20 | 1.00 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.67 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyruvate SCHEMBL1332722 | 1.00 | — | — | |
| Pyruvate SCHEMBL28324563 | 1.00 | CA4 (1.00) | CA4CA1FAHD1TSHRTHPO | |
| Pyruvate SCHEMBL1333219 | 1.00 | — | — | |
| Pyruvate SCHEMBL1332812 | 1.00 | — | — | |
| Pyruvate SCHEMBL1332703 | 1.00 | — | — | |
| Pyruvate SCHEMBL1332958 | 1.00 | — | — | |
| Pyruvate SCHEMBL1331761 | 1.00 | — | — | |
| Pyruvate SCHEMBL18226 | 1.00 | — | — | |
| Pyruvate SCHEMBL15541131 | 0.96 | — | — | |
| Pyruvate SCHEMBL20481652 | 0.96 | CA4 (0.92) | CA4CA1FAHD1TSHRTHPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112226416-A | Culture medium additive for hybridoma cell culture | 通山县金瑞生物科技研发中心 | 2021-01-15 | — | — | CN | claimed |
| CN-122038299-A | Induction medium for transdifferentiating cells into dopaminergic neuron source exosomes by using small molecular compound in vitro induction, culture method and application | 广西壮族自治区人民医院 | 2026-05-15 | — | — | CN | disclosed |
| CN-114214243-B | Enrichment and selective culture of Mycobacteria | 生物梅里埃公司 | 2024-06-11 | — | — | CN | disclosed |
| CN-114457001-B | Bracket material and preparation method and application thereof | 广东粤港澳大湾区国家纳米科技创新研究院 | 2024-05-03 | — | — | CN | disclosed |
| WO-2024008187-A1 | USE OF PRUNUS LANNESIANA EXTRACT IN PREPARATION OF DRUG FOR IMPROVING SKIN CONDITION OR BASAL METABOLIC RATE | 大江生医股份有限公司 | 2024-01-11 | — | — | WO | disclosed |
| CN-114645010-A | Low-protein serum-free cell culture medium for producing monoclonal antibody and application thereof | 南京基蛋生物医药有限公司 | 2022-06-21 | — | — | CN | disclosed |
| CN-114470001-A | Therapeutic use of human amniotic epithelial cells in autoimmune diseases | 浙江大学 | 2022-05-13 | — | — | CN | disclosed |
| CN-106834229-B | Serum-free culture medium for in vitro amplification of human immune killer cells | 华东理工大学 | 2021-08-17 | — | — | CN | disclosed |
| CN-110090228-A | Therapeutic use of human amniotic epithelial cells in autoimmune diseases | 浙江大学 | 2019-08-06 | — | — | CN | disclosed |
| CN-105602899-B | A kind of method of NK cell Proliferation in interleukin 21 and 4-1BBL induction peripheral blood mononuclear cells | 天津天锐生物科技有限公司 | 2019-03-08 | — | — | CN | disclosed |
| CN-103687619-A | Compositions and methods for the therapy and diagnosis of influenza | THERACLONE SCIENCES INC | 2014-03-26 | — | — | CN | disclosed |
| EP-2155810-A2 | ALGINATE COATED, POLYSACCHARIDE GEL-CONTAINING FOAM COMPOSITE, PREPARATIVE METHODS, AND USES THEREOF | FMC Corporation (US) | 2010-02-24 | — | — | EP | disclosed |
| CN-101396564-A | Protein capable of adjusting sperm capacitation and use thereof | SHANGHAI INST BIOL SCIENCES (CN) | 2009-04-01 | — | — | CN | disclosed |
| US-20090010983-A1 | Alginate Coated, Polysaccharide Gel-Containing Foam Composite, Preparative Methods, and Uses Thereof | FMC CORPORATION (US) | 2009-01-08 | — | — | US | disclosed |
| WO-2008157318-A2 | ALGINATE COATED, POLYSACCHARIDE GEL-CONTAINING FOAM COMPOSITE, PREPARATIVE METHODS, AND USES THEREOF | FMC CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |
| EP-1988942-A2 | GELLED COMPOSITE | FMC Biopolymer AS (NO) | 2008-11-12 | — | — | EP | disclosed |
| EP-1709151-A4 | COMPOSITIONS AND METHODS FOR PROPAGATION OF NEURAL PROGENITOR CELLS | CATHOLIC HEALTHCARE WEST (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2007103209-A2 | GELLED COMPOSITE | FMC BIOPOLYMER AS (NO) | 2007-09-13 | — | — | WO | disclosed |
| EP-1709151-A2 | COMPOSITIONS AND METHODS FOR PROPAGATION OF NEURAL PROGENITOR CELLS | Catholic Healthcare West (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005056755-A2 | COMPOSITIONS AND METHODS FOR PROPAGATION OF NEURAL PROGENITOR CELLS | CATHOLIC HEALTHCARE WEST (US) | 2005-06-23 | — | — | WO | disclosed |