Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.61 |
| ▸ | HTR2A | P28223 | 5/20 | 0.61 |
| ▸ | HTR1A | P08908 | 4/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | HTR2C | P28335 | 2/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.59 |
| ▸ | HRH1 | P35367 | 2/20 | 0.59 |
| ▸ | HTR6 | P50406 | 2/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1545461 | 0.86 | HTR1A (0.76) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| Anisole SCHEMBL3645349 | 0.85 | DRD2 (0.63) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| Methyl Alcohol SCHEMBL718326 | 0.81 | DRD2 (0.69) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| Methyl Alcohol SCHEMBL718327 | 0.81 | HTR1A (0.76) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| Methyl Alcohol SCHEMBL142049 | 0.81 | ABCB11 (0.66) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| SCHEMBL8714677 | 0.81 | HTR2A (0.62) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| Methyl Alcohol SCHEMBL929693 | 0.80 | CHRM2 (0.65) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| SCHEMBL22149696 | 0.80 | DRD2 (0.76) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| Alcohol SCHEMBL8713382 | 0.79 | HTR1A (0.69) | DRD2HTR2AHTR1AKCNH2HTR2C | |
| Alcohol SCHEMBL142048 | 0.79 | DRD2 (0.66) | DRD2HTR2AHTR1AKCNH2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2198049-A1 | ANTIPSYCHOTIC TREATMENT BASED ON SNP GENOTYPE | Vanda Pharmaceuticals Inc. (US) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009036056-A1 | ANTIPSYCHOTIC TREATMENT BASED ON SNP GENOTYPE | VANDA PHARMACEUTICALS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |