Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | HTT | P42858 | 6/20 | 0.38 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 2/20 | 0.37 |
| ▸ | FNTB | P49356 | 2/20 | 0.37 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365402 | 0.91 | PSEN1 (0.38) | MAPTHTTTSHRLMNANPSR1 | |
| SCHEMBL366695 | 0.90 | MKNK1 (0.41) | MAPTHTTTSHRLMNANPSR1 | |
| SCHEMBL366915 | 0.90 | PSEN1 (0.37) | MAPTHTTTSHRLMNANPSR1 | |
| SCHEMBL366073 | 0.85 | ALKBH1 (0.36) | MAPTNPSR1POLBPSEN1PSEN2 | |
| SCHEMBL366080 | 0.84 | ALDH1A1 (0.38) | MAPTHTTTSHRLMNANPSR1 | |
| SCHEMBL364641 | 0.83 | PLK1 (0.38) | MAPTNPSR1POLBPSEN1PSEN2 | |
| SCHEMBL365082 | 0.81 | CYP11B2 (0.40) | MAPTNPSR1CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL366906 | 0.81 | HTT (0.37) | MAPTHTTTSHRLMNANPSR1 | |
| SCHEMBL366565 | 0.78 | ALDH1A1 (0.39) | MAPTHTTPOLBPSEN1PSEN2 | |
| SCHEMBL364643 | 0.77 | CYP11B1 (0.40) | HTTTSHRLMNACYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |