Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365082 | 0.91 | CYP11B2 (0.40) | CYP11B2CYP11B1KDM4EALDH1A1HPGD | |
| SCHEMBL365103 | 0.90 | MAPT (0.38) | CYP11B2CYP11B1CYP19A1KDM4EALDH1A1 | |
| SCHEMBL364643 | 0.86 | CYP11B1 (0.40) | MKNK1MKNK2CYP11B2CYP11B1CYP19A1 | |
| SCHEMBL366016 | 0.85 | MAPK12 (0.39) | MKNK1MKNK2CYP11B2CYP11B1CYP19A1 | |
| SCHEMBL366915 | 0.84 | PSEN1 (0.37) | ALDH1A1LMNAMAPTTSHRHTT | |
| SCHEMBL365402 | 0.83 | PSEN1 (0.38) | KDM4EALDH1A1FNTAFNTBPGGT1B | |
| SCHEMBL366906 | 0.79 | HTT (0.37) | KDM4EALDH1A1LMNAMAPTTSHR | |
| SCHEMBL366694 | 0.78 | MKNK1 (0.41) | MKNK1MKNK2CYP11B2CYP11B1CYP19A1 | |
| SCHEMBL367194 | 0.77 | GPR132 (0.38) | HTTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL365965 | 0.76 | ACVR2A (0.38) | KDM4EAPPSNCALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |