Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PHGDH | O43175 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367333 | 0.89 | HPGD (0.52) | HPGDCNR2TSHRALDH1A1PHGDH | |
| SCHEMBL365335 | 0.85 | CNR2 (0.47) | HPGDCNR2ALDH1A1L3MBTL1CNR1 | |
| SCHEMBL365228 | 0.81 | HPGD (0.47) | HPGDCNR2TSHRCNR1KDM4E | |
| SCHEMBL365101 | 0.81 | KMT2A (0.51) | TSHRKDM4ECYP1A2SMN1; SMN2KMT2A | |
| SCHEMBL367764 | 0.80 | EGFR (0.45) | HPGDTSHRALDH1A1L3MBTL1KDM4E | |
| SCHEMBL365259 | 0.78 | KDM4E (0.44) | HPGDALDH1A1KDM4ECYP1A2 | |
| SCHEMBL367330 | 0.77 | EGFR (0.46) | HPGDALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL366310 | 0.76 | ALDH1A1 (0.52) | HPGDALDH1A1L3MBTL1CNR1KDM4E | |
| SCHEMBL365635 | 0.74 | IDO1 (0.44) | HPGDALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL366811 | 0.72 | EGFR (0.44) | HPGDTSHRALDH1A1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |