Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367564 | 0.99 | HPGD (0.50) | HPGDHTTTDP1LMNASMN1; SMN2 | |
| SCHEMBL366310 | 0.88 | ALDH1A1 (0.52) | HPGDSMN1; SMN2ALDH1A1POLBRAB9A | |
| SCHEMBL365544 | 0.88 | REN (0.53) | — | |
| SCHEMBL365014 | 0.81 | KDM4E (0.48) | HPGDHTTSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL365590 | 0.81 | KDM4E (0.51) | HPGDHTTTDP1LMNASMN1; SMN2 | |
| SCHEMBL365565 | 0.80 | KMT2A (0.52) | HPGDHTTTDP1LMNASMN1; SMN2 | |
| SCHEMBL364594 | 0.80 | EGFR (0.44) | HPGDHTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL367563 | 0.79 | KDM4E (0.52) | HPGDHTTTDP1LMNASMN1; SMN2 | |
| SCHEMBL364207 | 0.78 | EGFR (0.47) | HPGDHTTSMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL364969 | 0.76 | KDM4E (0.53) | HPGDHTTLMNAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |