Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.61 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.59 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3665032 | 0.91 | AGTR1 (0.57) | AGTR1AGTR2 | |
| SCHEMBL359 | 0.91 | GP6 (0.63) | GP6AGTR1AGTR2 | |
| SCHEMBL1258200 | 0.89 | GP6 (0.60) | GP6AGTR1AGTR2 | |
| SCHEMBL33 | 0.88 | AGTR1 (0.75) | GP6AGTR1AGTR2 | |
| SCHEMBL3661385 | 0.86 | AGTR2 (0.67) | AGTR1AGTR2 | |
| SCHEMBL16305582 | 0.82 | AGTR1 (0.59) | AGTR1AGTR2 | |
| SCHEMBL8792485 | 0.81 | AGTR1 (0.64) | GP6AGTR1AGTR2 | |
| SCHEMBL9123848 | 0.81 | AGTR1 (0.54) | AGTR1AGTR2 | |
| SCHEMBL8569736 | 0.81 | GP6 (0.69) | GP6AGTR1AGTR2 | |
| SCHEMBL8735381 | 0.81 | AGTR1 (0.68) | GP6AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146963-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | Theravance, Inc. (US) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008133896-A2 | DUAL-ACTING ANTIHYPERTENSIVE AGENTS | THERAVANCE, INC. (US) | 2008-11-06 | — | — | WO | disclosed |