Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.33 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | CRAT | P43155 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | CPT1A | P50416 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL718907 | 0.84 | SLC22A16 (0.45) | SLC22A16MEN1KMT2ACYP1A2HRH1 | |
| Iodide SCHEMBL10588910 | 0.82 | SLC22A16 (0.43) | SLC22A16MEN1KMT2ACYP1A2HRH1 | |
| Water SCHEMBL16341077 | 0.82 | SLC22A16 (0.43) | SLC22A16MEN1KMT2ACYP1A2HRH1 | |
| Hydrochloric Acid SCHEMBL9580738 | 0.82 | SLC22A16 (0.43) | SLC22A16MEN1KMT2ACYP1A2HRH1 | |
| Hydrochloric Acid SCHEMBL719321 | 0.82 | MAPT (0.43) | SLC22A16MEN1KMT2ACYP1A2HRH1 | |
| SCHEMBL15104879 | 0.82 | CPT2 (0.44) | CPT2CPT1A | |
| SCHEMBL2165563 | 0.78 | TSHR (0.46) | SLC22A16MEN1KMT2ACYP1A2HRH1 | |
| Methacrylic Acid SCHEMBL1874881 | 0.76 | POLB (0.33) | MEN1KMT2ACYP1A2HRH1POLB | |
| SCHEMBL7561035 | 0.75 | TGFBR1 (0.39) | MEN1KMT2ACYP1A2HRH1TSHR | |
| SCHEMBL10384583 | 0.75 | ALDH1A1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220008543-A1 | MACROMOLECULAR PRODRUG-BASED THERMOSENSITIVE INJECTABLE GEL AS A NOVEL DRUG DELIVERY PLATFORM | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-01-13 | — | — | US | claimed |
| CN-107522809-B | Charge-reversible ion exchange resins, chromatography columns, methods, and systems thereof | 戴安公司 | 2020-04-10 | — | — | CN | claimed |
| US-10379090-B2 | Charge reversible ion exchange resins, chromatography column, method, and system thereof | DIONEX CORPORATION (US) | 2019-08-13 | — | — | US | claimed |
| US-20180318773-A1 | COMPOSITE MATERIAL COMPRISING A NON-CROSSLINKED GEL POLYMER | MCMASTER UNIVERSITY | 2018-11-08 | — | — | US | claimed |
| EP-3269394-A1 | MACROMOLECULAR DELIVERY SYSTEMS FOR NON-INVASIVE IMAGING, EVALUATION AND TREATMENT OF ARTHRITIS AND OTHER INFLAMMATORY DISEASES | University of Utah Research Foundation (US) | 2018-01-17 | — | — | EP | claimed |
| US-20170363592-A1 | CHARGE REVERSIBLE ION EXCHANGE RESINS, CHROMATOGRAPHY COLUMN, METHOD, AND SYSTEM THEREOF | DIONEX CORPORATION | 2017-12-21 | — | — | US | claimed |
| US-20160166693-A1 | RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2016-06-16 | — | — | US | claimed |
| US-20120197060-A1 | RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY TECHNOLOGY | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2012-08-02 | — | — | US | claimed |
| JP-4805939-B2 | — | — | 2011-11-02 | — | — | JP | claimed |
| US-7883767-B2 | two or more consecutive pore-coating layers to a porous support to achieve very hydrophilic composite materials; 1st gel polymer layer having both hydrophobic and hydrophilic properties, second polymer layer which durably coats the surface of the first polymer layer being more hydrophilic than first | MCMASTER UNIVERSITY (CA) | 2011-02-08 | — | — | US | claimed |
| EP-1793916-A4 | COMPOSITE MATERIAL COMPRISING LAYERED HYDROPHILIC COATINGS | UNIV MCMASTER (CA) | 2008-05-14 | — | — | EP | claimed |
| EP-1793916-A1 | COMPOSITE MATERIAL COMPRISING LAYERED HYDROPHILIC COATINGS | McMaster University (CA) | 2007-06-13 | — | — | EP | claimed |
| EP-1776176-A1 | COMPOSITE MATERIAL COMPRISING A NON-CROSSLINKED GEL POLYMER | McMaster University (CA) | 2007-04-25 | — | — | EP | claimed |
| EP-1737428-A1 | MACROMOLECULAR DELIVERY SYSTEMS FOR NON-INVASIVE IMAGING, EVALUATION AND TREATMENT OF ARTHRITIS AND OTHER INFLAMMATORY DISEASES | University of Utah Research Foundation (US) | 2007-01-03 | — | — | EP | claimed |
| US-20060121217-A1 | Composite material comprising layered hydrophilic coatings | MCMASTER UNIVERSITY | 2006-06-08 | — | — | US | claimed |
| WO-2006034575-A1 | COMPOSITE MATERIAL COMPRISING LAYERED HYDROPHILIC COATINGS | MCMASTER UNIVERSITY (CA) | 2006-04-06 | — | — | WO | claimed |
| WO-2006015495-A1 | COMPOSITE MATERIAL COMPRISING A NON-CROSSLINKED GEL POLYMER | MCMASTER UNIVERSITY (CA) | 2006-02-16 | — | — | WO | claimed |
| US-20050287114-A1 | Water-soluble polymeric bone-targeting drug delivery system | UNIVERSITY OF UTAH RESEARCH FOUNDATION | 2005-12-29 | — | — | US | claimed |
| WO-2005097073-A1 | MACROMOLECULAR DELIVERY SYSTEMS FOR NON-INVASIVE IMAGING, EVALUATION AND TREATMENT OF ARTHRITIS AND OTHER INFLAMMATORY DISEASES | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2005-10-20 | — | — | WO | claimed |
| WO-2004062588-A2 | WATER-SOLUBLE POLYMERIC BONE-TARGETING DRUG DELIVERY SYSTEM | UNIVERSITY OF UTAH (US) | 2004-07-29 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160166693-A1 | RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY | MRE11, TOP2A, MTREX | CHRM1 4676/4885SLC22A16 2466/4885MEN1 1511/4885 |
| US-20050287114-A1 | Water-soluble polymeric bone-targeting drug delivery system | HPGDS, CD44, BMP2 | CHRM1 2206/4885SLC22A16 169/4885MEN1 1950/4885 |
| US-20220008543-A1 | MACROMOLECULAR PRODRUG-BASED THERMOSENSITIVE INJECTABLE GEL AS A NOVEL DRUG DELIVERY PLATFORM | PLG, PYGL, PPIG | CHRM1 4724/4885SLC22A16 497/4885MEN1 425/4885 |
| US-20120197060-A1 | RADIATION ENHANCED MACROMOLECULAR DELIVERY OF THERAPEUTIC AGENTS FOR CHEMOTHERAPY TECHNOLOGY | MRE11, MTREX, POLG | CHRM1 4671/4885SLC22A16 2404/4885MEN1 1629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.