Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 11/20 | 0.50 |
| ▸ | SCN2B | O60939 | 9/20 | 0.50 |
| ▸ | SCN1B | Q07699 | 9/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 8/20 | 0.50 |
| ▸ | SCN1A | P35498 | 7/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366354 | 0.88 | SCN9A (0.46) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL366978 | 0.85 | SCN9A (0.45) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL366371 | 0.84 | EGFR (0.45) | AGTR1EGFRSRC | |
| SCHEMBL365935 | 0.81 | KDM4E (0.47) | AGTR1EGFRSRC | |
| SCHEMBL366783 | 0.81 | SCN9A (0.54) | SCN9ASCN2BSCN1BSCN5ASCN1A | |
| SCHEMBL366876 | 0.80 | EGFR (0.44) | AGTR1EGFRSRC | |
| SCHEMBL367747 | 0.78 | AGTR1 (0.48) | AGTR1EGFR | |
| SCHEMBL365909 | 0.78 | LMNA (0.45) | SCN9AAGTR1EGFRSRC | |
| SCHEMBL365666 | 0.77 | HPGD (0.52) | EGFRSRC | |
| SCHEMBL366811 | 0.77 | EGFR (0.44) | AGTR1EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |