Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.63 |
| ▸ | NOD2 known ✓ | Q9HC29 | 1/20 | 0.63 |
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | MITF | O75030 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL203512 | 0.98 | MAOB (0.76) | MAOBALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL29352381 | 0.98 | MAOB (0.76) | MAOBALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL30393189 | 0.98 | MAOB (0.76) | MAOBALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL4060068 | 0.98 | MAOB (0.76) | MAOBALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL28969425 | 0.98 | MAOB (0.76) | MAOBALDH1A1MAPTSMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL30042874 | 0.96 | MAOB (0.73) | MAOBALDH1A1MAPTSMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL9360345 | 0.96 | MAOB (0.73) | MAOBALDH1A1MAPTSMN1; SMN2MEN1 | |
| Ammonia Solution, Strong SCHEMBL9154424 | 0.96 | MAOB (0.73) | MAOBALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL8020282 | 0.94 | ALDH1A1 (0.73) | MAOBALDH1A1MAPTSMN1; SMN2MEN1 | |
| SCHEMBL261579 | 0.94 | ALDH1A1 (0.73) | MAOBALDH1A1MAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2623802-A1 | RETAINER FOR ROLLING BEARING, AND ROLLING BEARING | NTN Corporation (JP) | 2013-08-07 | — | — | EP | disclosed |
| US-20130182987-A1 | CAGE FOR ROLLING BEARING AND ROLLING BEARING | NTN CORPORATION (JP) | 2013-07-18 | — | — | US | disclosed |
| US-8449200-B2 | Resin composition for sliding member and rolling bearing | NTN CORPORATION (JP) | 2013-05-28 | — | — | US | disclosed |
| US-8182155-B2 | Lubricating grease and lubricating grease-enclosed roller bearing | NTN CORPORATION (JP) | 2012-05-22 | — | — | US | disclosed |
| US-20100142872-A1 | RESIN COMPOSITION FOR SLIDING MEMBER AND ROLLING BEARING | NTN CORPORATION (JP) | 2010-06-10 | — | — | US | disclosed |
| EP-2157135-A1 | RESIN COMPOSITION FOR SLIDE MEMBER AND ROLLER BEARING | NTN Corporation (JP) | 2010-02-24 | — | — | EP | disclosed |
| US-20090232432-A1 | Lubricating grease and lubricating grease-enclosed roller bearing | NTN CORPORATION (JP) | 2009-09-17 | — | — | US | disclosed |
| EP-1956072-A1 | LUBRICATING GREASE AND LUBRICATING-GREASE-FILLED ROLLER BEARING | NTN CORPORATION (JP) | 2008-08-13 | — | — | EP | disclosed |