Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 7/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3669947 | 1.00 | AMY1A (0.65) | AMY1ALMNAHSD17B10TSHRKMT2A | |
| SCHEMBL5873306 | 0.81 | CYP1A2 (0.56) | KMT2AALDH1A1MEN1KDM4EHPGD | |
| SCHEMBL14276077 | 0.81 | CYP1A2 (0.56) | KMT2AALDH1A1MEN1KDM4EHPGD | |
| SCHEMBL13401702 | 0.76 | LMNA (0.57) | AMY1ALMNAHSD17B10TSHRKMT2A | |
| SCHEMBL5310365 | 0.76 | AMY1A (0.71) | AMY1ALMNAHSD17B10TSHRKMT2A | |
| SCHEMBL5310368 | 0.76 | AMY1A (0.71) | AMY1ALMNAHSD17B10TSHRKMT2A | |
| SCHEMBL4956254 | 0.73 | POLB (0.57) | HSD17B10KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL2494935 | 0.72 | LMNA (0.79) | AMY1ALMNATSHRALDH1A1KDM4E | |
| SCHEMBL2494933 | 0.72 | LMNA (0.79) | AMY1ALMNATSHRALDH1A1KDM4E | |
| SCHEMBL9465026 | 0.71 | CA12 (0.59) | KMT2AALDH1A1MEN1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100104644-A1 | Compositions and Methods for Treating or Preventing Ophthalmic Disease | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-04-29 | — | — | US | claimed |
| US-20090291919-A1 | Compositions and Methods for Treating or Preventing Ophthalmic Light Toxicity | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-11-26 | — | — | US | claimed |
| US-20090286808-A1 | Opsin Stabilizing Compounds and Methods of Use | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-11-19 | — | — | US | claimed |
| EP-2069390-A2 | OPSIN STABILIZING COMPOUNDS AND METHODS OF USE | University of Florida Research Foundation, Inc. (US) | 2009-06-17 | — | — | EP | claimed |
| EP-2069391-A2 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING OPHTHALMIC DISEASE | University of Florida Research Foundation, Inc. (US) | 2009-06-17 | — | — | EP | claimed |
| WO-2008013984-A2 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING OPHTHALMIC DISEASE | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2008-01-31 | — | — | WO | claimed |
| WO-2008013986-A2 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING OPHTHALMIC LIGHT TOXICITY | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2008-01-31 | — | — | WO | claimed |
| WO-2008013983-A2 | OPSIN STABILIZING COMPOUNDS AND METHODS OF USE | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2008-01-31 | — | — | WO | claimed |
| US-4064059-A | ALIPHATIC ESTER, SUBSTITUTED 4-AMINO-TRIAZOLE, A PHENYLNAPHTHYLAMINE, DIALKYLDIPHENYLAMINE, HYDROCARBYL PHOSPHATE ESTER | TEXACO INC. (US) | 1977-12-20 | — | — | US | claimed |
| US-20100104644-A1 | Compositions and Methods for Treating or Preventing Ophthalmic Disease | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| US-20090291919-A1 | Compositions and Methods for Treating or Preventing Ophthalmic Light Toxicity | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-11-26 | — | — | US | disclosed |
| US-20090286808-A1 | Opsin Stabilizing Compounds and Methods of Use | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-11-19 | — | — | US | disclosed |
| EP-2069390-A2 | OPSIN STABILIZING COMPOUNDS AND METHODS OF USE | University of Florida Research Foundation, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| EP-2069391-A2 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING OPHTHALMIC DISEASE | University of Florida Research Foundation, Inc. (US) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008013984-A2 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING OPHTHALMIC DISEASE | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2008-01-31 | — | — | WO | disclosed |
| WO-2008013983-A2 | OPSIN STABILIZING COMPOUNDS AND METHODS OF USE | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291919-A1 | Compositions and Methods for Treating or Preventing Ophthalmic Light Toxicity | ALDH1A2, EYA3, PDE6C | AMY1A 3101/4885LMNA 1092/4885HSD17B10 1183/4885 |
| US-20100104644-A1 | Compositions and Methods for Treating or Preventing Ophthalmic Disease | ALDH1A2, PDE6C, EYA3 | AMY1A 2995/4885LMNA 979/4885HSD17B10 971/4885 |
| US-20090286808-A1 | Opsin Stabilizing Compounds and Methods of Use | CRYZ, NR2E3, CRYAB | AMY1A 3380/4885LMNA 1096/4885HSD17B10 2560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.