Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366462 | 0.90 | LMNA (0.46) | EGFRLMNAHTTKDM4EALDH1A1 | |
| SCHEMBL364787 | 0.86 | KMT2A (0.45) | LMNAHTTKDM4EALDH1A1MEN1 | |
| SCHEMBL367707 | 0.85 | EGFR (0.44) | EGFRSRCLMNAMEN1KMT2A | |
| SCHEMBL366998 | 0.81 | HTT (0.46) | EGFRSRCLMNAHTTKDM4E | |
| SCHEMBL366741 | 0.78 | EGFR (0.38) | EGFRSRCMEN1KMT2A | |
| SCHEMBL367764 | 0.76 | EGFR (0.45) | EGFRSRCLMNAHTTKDM4E | |
| SCHEMBL367201 | 0.76 | EGFR (0.45) | EGFRSRCKDM4EALDH1A1 | |
| SCHEMBL367330 | 0.75 | EGFR (0.46) | EGFRSRCKDM4EALDH1A1KMT2A | |
| SCHEMBL366109 | 0.75 | EGFR (0.43) | EGFRSRCKDM4EALDH1A1 | |
| SCHEMBL367283 | 0.74 | RAB9A (0.44) | EGFRSRCLMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |