Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 5/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CCR6 | P51684 | 3/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | CCR7 | P32248 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365147 | 0.90 | AGTR1 (0.39) | EGFRHTR2AHTR2CMEN1KMT2A | |
| SCHEMBL364653 | 0.82 | CA2 (0.43) | EGFRSRCHTR2AHTR2CAGTR1 | |
| SCHEMBL367707 | 0.81 | EGFR (0.44) | EGFRSRCHTR2AHTR2CMEN1 | |
| SCHEMBL366740 | 0.80 | KDM4E (0.36) | EGFRSRCHTR2AHTR2CMEN1 | |
| SCHEMBL366999 | 0.78 | EGFR (0.42) | EGFRSRCMEN1KMT2A | |
| SCHEMBL366926 | 0.77 | ALDH1A1 (0.36) | EGFRSRCHTR2AHTR2CMEN1 | |
| SCHEMBL367201 | 0.75 | EGFR (0.45) | EGFRSRCHTR2AHTR2CAGTR1 | |
| SCHEMBL367764 | 0.75 | EGFR (0.45) | EGFRSRCHTR2AHTR2CMEN1 | |
| SCHEMBL365648 | 0.73 | CA9 (0.45) | EGFRAGTR1CA12CA1CA2 | |
| SCHEMBL365259 | 0.72 | KDM4E (0.44) | EGFRSRCHTR2AHTR2CAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |