SCHEMBL3671609

SCHEMBL3671609

CN(Cc1cccc(-c2cc(C(F)(F)F)ccc2[O])c1)C(=O)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 1/20 0.52
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
TACR1 P25103 5/20 0.51
PDK1 Q15118 1/20 0.49
HSD17B2 P37059 4/20 0.47
HSD17B1 P14061 3/20 0.47
TRPM8 Q7Z2W7 1/20 0.46
HDAC1 Q13547 2/20 0.45
HDAC6 Q9UBN7 2/20 0.45
HDAC3 O15379 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC7 Q8WUI4 1/20 0.45
HDAC2 Q92769 1/20 0.45
HDAC5 Q9UQL6 1/20 0.45
MTOR P42345 1/20 0.44
AOC3 Q16853 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3671611 0.89 PDK1 (0.54) MLYCDMEN1KMT2ATACR1PDK1
SCHEMBL3670285 0.88 TRPV4 (0.43) MLYCDMEN1KMT2ATACR1HSD17B2
SCHEMBL3666874 0.84 ABHD6 (0.54) MEN1KMT2ATACR1HSD17B2MTOR
SCHEMBL3668636 0.84 MTOR (0.64) MEN1KMT2ATACR1MTORAOC3
SCHEMBL1947876 0.84 PTGDR2 (0.64) MLYCDMEN1KMT2ATACR1
SCHEMBL3667568 0.81 MGLL (0.42) MEN1KMT2ATACR1
SCHEMBL3666865 0.80 HDAC6 (0.56) MEN1KMT2ATACR1PDK1HDAC6
SCHEMBL3672476 0.79 MTOR (0.43) TACR1HDAC1HDAC6HDAC3HDAC2
SCHEMBL3668838 0.78 NR1H3 (0.51) MEN1KMT2AHSD17B2HSD17B1TRPM8
SCHEMBL3666331 0.78 MTOR (0.47) TACR1MTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2240434-A1 2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS Ligand Pharmaceuticals Inc. (US) 2010-10-20 EP disclosed
WO-2009089192-A1 2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS LIGAND PHARMACEUTICALS INC. (US) 2009-07-16 WO disclosed