SCHEMBL3678842

SCHEMBL3678842

CC(=O)ON1C(=O)CC(C)C1=O

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.33
HPGD P15428 1/20 0.33
POLB P06746 1/20 0.33
BRD4 O60885 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4326673 0.81 POLB (0.33) POLBBRD4
SCHEMBL14437893 0.80 POLB (0.32) MAPTPOLB
SCHEMBL12088177 0.80 POLB (0.31) POLB
SCHEMBL18179999 0.80 CHRM1 (0.32) BRD4
SCHEMBL10068094 0.80 CHRM2 (0.33) HPGDBRD4
SCHEMBL16856451 0.79 POLB (0.32) POLB
SCHEMBL12642095 0.79 ADAM17 (0.44) POLB
SCHEMBL6802326 0.79 POLB (0.32) POLB
SCHEMBL23071802 0.79 BRD4 (0.31) BRD4
SCHEMBL208987 0.79 PRKCA (0.35) BRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3737418-B1 POLYMERS WITH RIGID SPACING GROUPS COMPRISING BIOLOGICALLY ACTIVE COMPOUNDS SONY GROUP CORP (JP) 2024-02-28 EP disclosed
US-20230285580-A1 ANTI-IL-13RALPHA2 CONJUGATES OWL ROCK OPPORTUNISTIC MASTER FUND I, L.P. 2023-09-14 US disclosed
US-20220153697-A1 RIGIDIFIED PENTADENTATE CHELATING AGENTS USEFUL FOR THE [AL18F]2+ LABELLING OF BIOMOLECULES UNIVERSITÀ DEGLI STUDI DEL PIEMONTE ORIENTALE "A. AVOGADRO" (IT) 2022-05-19 US disclosed
EP-3512856-B1 NOVEL CYTOTOXIC AGENTS AND CONJUGATES THEREOF POLYTHERICS LTD (GB) 2021-03-24 EP disclosed
EP-3753578-A1 CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF Novartis AG (CH) 2020-12-23 EP disclosed
US-10633418-B2 Cross-linked peptides containing non-peptide cross-linked structure, method for synthesizing cross-linked peptides, and novel organic compound used in method JITSUBO CO., LTD. (JP) 2020-04-28 US disclosed
US-20170354743-A1 SITE SELECTIVE CONJUGATION OF AN OLIGONUCLEOTIDE CONJUGATE OR A SMALL MOLECULE TO A METAL BINDING PROTEIN AFFYCON APS (DK) 2017-12-14 US disclosed
US-20170340752-A1 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF MEDIMMUNE LIMITED (GB) 2017-11-30 US disclosed
US-9821074-B2 Pyrrolobenzodiazepines and conjugates thereof GENENTECH, INC. (US) 2017-11-21 US disclosed
US-20170258934-A1 PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES OWL ROCK OPPORTUNISTIC MASTER FUND I, L.P. 2017-09-14 US disclosed
US-7588701-B2 Cored dendrimer comprising crosslinked dendrons surrounding a central interior region that is free of organic material, a semiconductor particle within cored dendrimer, having a size that is no greater than an outer dimension of cored dendrimer and that is greater than central interior region 3M INNOVATIVE PROPERTIES COMPANY (US) 2009-09-15 US disclosed
US-20080265221-A1 TEMPLATED SEMICONDUCTOR PARTICLES AND METHODS OF MAKING 3M INNOVATIVE PROPERTIES COMPANY 2008-10-30 US disclosed
US-7413607-B2 Templated semiconductor particles and methods of making 3M INNOVATIVE PROPERTIES COMPANY (US) 2008-08-19 US disclosed
US-20080152911-A1 TEMPLATED METAL PARTICLES AND METHODS OF MAKING 3M INNOVATIVE PROPERTIES COMPANY 2008-06-26 US disclosed
US-7344583-B2 Methods of making metal particles within cored dendrimers 3M INNOVATIVE PROPERTIES COMPANY (US) 2008-03-18 US disclosed
US-7316931-B2 Mass defect labeling for the determination of oligomer sequences TARGET DISCOVERY, INC. (US) 2008-01-08 US disclosed
US-20060281629-A1 Catalyst comprising N-substituted cyclic imide compound and process for producing organic compound using the catalyst ISHII YASUTAKA 2006-12-14 US disclosed
US-7115541-B2 Catalyst comprising n-substituted cyclic imides and processes for preparing organic compounds with the catalyst DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2006-10-03 US disclosed
EP-1338336-A1 CATALYSTS COMPRISING N-SUBSTITUTED CYCLIC IMIDES AND PROCESSES FOR PREPARING ORGANIC COMPOUNDS WITH THE CATALYSTS Daicel Chemical Industries, Ltd. (JP) 2003-08-27 EP disclosed
US-20030013603-A1 Catalyst comprising n-substituted cylic imides and processes for preparing organic compounds with the catalyst DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2003-01-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220153697-A1 RIGIDIFIED PENTADENTATE CHELATING AGENTS USEFUL FOR THE [AL18F]2+ LABELLING OF BIOMOLECULES SLC29A1, APRT, SLC29A2 MAPT 2824/4885HPGD 4486/4885POLB 2500/4885
US-20170258934-A1 PYRROLOBENZODIAZEPINE-ANTIBODY CONJUGATES IL2RA, CD2, CD4 MAPT 913/4885HPGD 361/4885POLB 3203/4885
US-20230285580-A1 ANTI-IL-13RALPHA2 CONJUGATES IL2RA, IL15RA, IL23R MAPT 2402/4885HPGD 2742/4885POLB 3661/4885
US-20060281629-A1 Catalyst comprising N-substituted cyclic imide compound and process for producing organic compound using the catalyst NOS2, NOS1, NOS3 MAPT 4792/4885HPGD 301/4885POLB 2011/4885
US-10633418-B2 Cross-linked peptides containing non-peptide cross-linked structure, method for synthesizing cross-linked peptides, and novel organic compound used in method VIP, NRDC, PTMS MAPT 3566/4885HPGD 1567/4885POLB 2337/4885
US-20170354743-A1 SITE SELECTIVE CONJUGATION OF AN OLIGONUCLEOTIDE CONJUGATE OR A SMALL MOLECULE TO A METAL BINDING PROTEIN CD2BP2, CACYBP, CALCOCO2 MAPT 3397/4885HPGD 4659/4885POLB 1378/4885
US-20170340752-A1 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF CD22, GABRA1, CCNB1 MAPT 4431/4885HPGD 3753/4885POLB 2621/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.