Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.49 |
| ▸ | CHUK | O15111 | 3/20 | 0.49 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.49 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.43 |
| ▸ | PLK4 | O00444 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29598166 | 0.80 | ALDH1A1 (0.48) | IKBKBCHUKIKBKEPKMYT1FGFR1 | |
| SCHEMBL24499499 | 0.80 | ALDH1A1 (0.48) | IKBKBCHUKIKBKEPKMYT1FGFR1 | |
| SCHEMBL29598295 | 0.79 | LDHA (0.46) | PTPN1CHEK2PLK4AURKADAPK3 | |
| SCHEMBL25973455 | 0.78 | TDO2 (0.48) | CHEK2PLK4AURKADAPK3CDK1 | |
| SCHEMBL9847043 | 0.76 | KDM4C (0.56) | MKNK1MKNK2PTPN1HNF4AACMSD | |
| SCHEMBL9803915 | 0.75 | KDM4E (0.50) | MCL1KDRKDM4C | |
| SCHEMBL12292220 | 0.74 | PTPN1 (0.66) | IKBKBCHUKIKBKEPKMYT1MAP4K4 | |
| SCHEMBL758071 | 0.73 | HNF4A (0.63) | IKBKBCHUKIKBKEPKMYT1PTPN1 | |
| SCHEMBL22258410 | 0.72 | ALDH1A1 (0.48) | CHEK2PLK4AURKADAPK3CDK1 | |
| SCHEMBL2811220 | 0.72 | ALDH1A1 (0.48) | MKNK1MKNK2PTPN1PIM1HNF4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120014918-A1 | ADDITION SALTS OF AMINES CONTAINING HYDROXYL AND/OR CARBOXYLIC GROUPS WITH AMINO NICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | ALMIRALL, S.A. (ES) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120014918-A1 | ADDITION SALTS OF AMINES CONTAINING HYDROXYL AND/OR CARBOXYLIC GROUPS WITH AMINO NICOTINIC ACID DERIVATIVES AS DHODH INHIBITORS | DHODH, DAO, ADH1B | IKBKB 1530/4885CHUK 957/4885IKBKE 2461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.