Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 5/20 | 0.41 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.39 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.38 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL3683871 | 1.00 | DRD2 (0.41) | DRD2HTR1ADRD4HTR2AHTR2C | |
| SCHEMBL3675794 | 0.94 | DRD2 (0.45) | DRD2HTR1ADRD4HTR2AHTR2C | |
| SCHEMBL3684227 | 0.85 | DRD2 (0.49) | DRD2HTR1ADRD4HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL3680042 | 0.84 | DRD2 (0.51) | DRD2HTR1ADRD4HTR2AHTR2C | |
| SCHEMBL7473873 | 0.81 | DRD2 (0.47) | DRD2HTR1ADRD4HTR2AHTR2C | |
| SCHEMBL7473725 | 0.80 | DRD2 (0.47) | DRD2HTR1ADRD4HTR2AHTR2C | |
| SCHEMBL7472342 | 0.79 | DRD2 (0.49) | DRD2HTR1A | |
| Piclozotan SCHEMBL562627 | 0.79 | SIGMAR1 (0.54) | DRD2HTR1ADRD4HTR2AHTR2C | |
| Piclozotan SCHEMBL29379540 | 0.79 | SIGMAR1 (0.54) | DRD2HTR1ADRD4HTR2AHTR2C | |
| Piclozotan SCHEMBL30249060 | 0.79 | SIGMAR1 (0.54) | DRD2HTR1ADRD4HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204202-A1 | DRUG FOR ALLEVIATING MOTOR COMPLICATIONS OR PSYCHIATRIC SYMPTOMS OF PARKINSON'S DISEASE | ASUBIO PHARMA CO., LTD. (JP) | 2010-08-12 | — | — | US | disclosed |
| EP-2213290-A1 | AGENT FOR IMPROVING MOTOR COMPLICATIONS OR PSYCHIATRIC SYMPTOMS IN PARKINSON'S DISEASE | Asubio Pharma Co., Ltd. (JP) | 2010-08-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204202-A1 | DRUG FOR ALLEVIATING MOTOR COMPLICATIONS OR PSYCHIATRIC SYMPTOMS OF PARKINSON'S DISEASE | SLC6A3, HTR3A, PARK7 | DRD2 8/4885HTR1A 4/4885HTR2A 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.