Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.34 |
| ▸ | ARG1 | P05089 | 1/20 | 0.33 |
| ▸ | ARG2 | P78540 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 4/20 | 0.32 |
| ▸ | PPARA | Q07869 | 4/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | ACACA | Q13085 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15012335 | 0.98 | CYP2C9 (0.35) | CYP2C9ALDH1A1CYP4F2CYP4A11ARG1 | |
| SCHEMBL16862076 | 0.98 | CYP2C9 (0.35) | CYP2C9ALDH1A1CYP4F2CYP4A11ARG1 | |
| SCHEMBL16171396 | 0.82 | TSHR (0.32) | ALDH1A1TSHRTHRBCA2CNR2 | |
| SCHEMBL1158850 | 0.80 | — | — | |
| SCHEMBL15012611 | 0.80 | MEN1 (0.48) | CYP2C9ALDH1A1CYP4F2CYP4A11ACLY | |
| SCHEMBL2183590 | 0.80 | DGAT1 (0.35) | ALDH1A1TSHRTHRBCNR2PRSS1 | |
| SCHEMBL16171407 | 0.80 | CA2 (0.33) | ALDH1A1TSHRTHRBCA2 | |
| SCHEMBL8052693 | 0.80 | CYP2C9 (0.42) | CYP2C9ALDH1A1CYP4F2CYP4A11ACLY | |
| SCHEMBL2597342 | 0.79 | CYP2C9 (0.37) | CYP2C9ALDH1A1ACLYTSHRACACB | |
| SCHEMBL3687624 | 0.79 | CYP2C9 (0.37) | CYP2C9ALDH1A1CYP4F2CYP4A11ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105705508-B | Acyclonucleosides phosphoric acid ester derivant and preparation method thereof and application medically | 四川海思科制药有限公司 | 2017-09-01 | — | — | CN | disclosed |
| CN-105705508-A | Acyclic nucleoside phosphonate derivative and preparation method and use thereof in medical science | 四川海思科制药有限公司 | 2016-06-22 | — | — | CN | disclosed |
| US-20160046576-A1 | NOVEL PYRROLE DERIVATIVES | UNIV LEICESTER (GB) | 2016-02-18 | — | — | US | disclosed |
| US-20160046576-A1 | NOVEL PYRROLE DERIVATIVES | UNIV LEICESTER (GB) | 2016-02-18 | — | — | US | disclosed |
| US-20160046576-A1 | NOVEL PYRROLE DERIVATIVES | UNIV LEICESTER (GB) | 2016-02-18 | — | — | US | disclosed |
| US-9221756-B2 | Pyrrole derivatives | UNIVERSITY OF LEICESTER (GB) | 2015-12-29 | — | — | US | disclosed |
| US-9221756-B2 | Pyrrole derivatives | UNIVERSITY OF LEICESTER (GB) | 2015-12-29 | — | — | US | disclosed |
| US-9221756-B2 | Pyrrole derivatives | UNIVERSITY OF LEICESTER (GB) | 2015-12-29 | — | — | US | disclosed |
| WO-2015096697-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF IN MEDICAL SCIENCE | 四川海思科制药有限公司 | 2015-07-02 | — | — | WO | disclosed |
| WO-2015096697-A1 | ACYCLIC NUCLEOSIDE PHOSPHONATE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF IN MEDICAL SCIENCE | 四川海思科制药有限公司 | 2015-07-02 | — | — | WO | disclosed |
| US-7825134-B2 | Amelioration of cataracts, macular degeneration and other ophthalmic diseases | OTHERA HOLDING, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| US-7825134-B2 | Amelioration of cataracts, macular degeneration and other ophthalmic diseases | OTHERA HOLDING, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| US-7825134-B2 | Amelioration of cataracts, macular degeneration and other ophthalmic diseases | OTHERA HOLDING, INC. (US) | 2010-11-02 | — | — | US | disclosed |
| US-20080274983-A1 | Amelioration Of The Development Of Cataracts And Other Ophthalmic Diseases | OTHERA HOLDING, INC. (US) | 2008-11-06 | — | — | US | disclosed |
| US-20080274983-A1 | Amelioration Of The Development Of Cataracts And Other Ophthalmic Diseases | OTHERA HOLDING, INC. (US) | 2008-11-06 | — | — | US | disclosed |
| US-20080274983-A1 | Amelioration Of The Development Of Cataracts And Other Ophthalmic Diseases | OTHERA HOLDING, INC. (US) | 2008-11-06 | — | — | US | disclosed |
| US-7442711-B2 | Amelioration of the development of cataracts and other ophthalmic diseases | OTHERA HOLDING, INC. (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442711-B2 | Amelioration of the development of cataracts and other ophthalmic diseases | OTHERA HOLDING, INC. (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442711-B2 | Amelioration of the development of cataracts and other ophthalmic diseases | OTHERA HOLDING, INC. (US) | 2008-10-28 | — | — | US | disclosed |
| US-20050131025-A1 | Amelioration of cataracts, macular degeneration and other ophthalmic diseases | COLBY PHARMACEUTICAL COMPANY | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080274983-A1 | Amelioration Of The Development Of Cataracts And Other Ophthalmic Diseases | C3AR1, C1R, AKR1C3 | CYP2C9 1154/4885ALDH1A1 756/4885CYP4F2 1332/4885 |
| US-20050131025-A1 | Amelioration of cataracts, macular degeneration and other ophthalmic diseases | C1R, CRYAB, C9 | CYP2C9 2207/4885ALDH1A1 1080/4885CYP4F2 2422/4885 |
| US-20160046576-A1 | NOVEL PYRROLE DERIVATIVES | PYCR1, ARG1, PNISR | CYP2C9 1801/4885ALDH1A1 2720/4885CYP4F2 897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.